First Aid Immunity Flashcards
Innate Immunity
Receptors recognize germ line encoded pathogens
Fast non specific response
Neutrophils Macrophages Dendritic Cells Natural Killer cells Complement
Adaptive immunity
V(D)J recombination
slow response
Faster with memory
T cell
B cells
Circulating Antibody
NK Cells
induce apoptosis of virally infected cells
B cell Function
Make antibodies
Opsonize bacteria
Neutralize Viruses
Activate compliment
Sensitize mast cells
B cell fx/ IgM, IgG
Activate compliment
B cell fx/ IgG
opsonize bacteria, neutralize viruses
B cell fx/ IgE
sensitize mast cells
T cell Fx
CD4 + T cells help B cell make antibody and produce cytokines
FAB
antigen binding fragment
Determines Idiotype
Fc
Constant Antibody region
Antibody diversity
Random VJ (light)or VJD recombo Addition of nucleotides during recombo
IgG characteristics
Main antibody
Most abundant
Crosses Placenta
IgG Functions
Delayed (2) response
- opsonizes bacteria
- neutralizes bacterial Toxins
IgA
Prevents attachment of bacteria and virus to mucous membrane
Found in secretions
IgM
Immediate (1) response
Fixes complement
Pentamer shape
IgD
Unclear fx
IgE
binds mast cells and basophiles
allergens cause Cross links
Immediate response through mediator release (Histamine)
Classic Pathway
IgG or IgM mediated
(GM makes classic cars)
Antigen-antibody complexes
Immune response
C3b fx
C3b Binds Bacteria
Immune response
C3a, C5a
anaphylaxis
Live attenuated vaccine
Cellular response
Pro: strong immunity
Con: may become virulent
Inactivated Vaccine
Humoral Immunity
Pro: stable and safer
Con: weaker response, booster shots needed
IgG half life
3 weeks
Th1 cytokine
Interferon gama
IFN gama
Interferon gama function
Chemotaxis for monocytes
Attracts MANY macrophages/monocytes
Made by Th1
M1 macrophages
Macrophages attracted be Th1
