BL- OSTEOARTHRITIS Flashcards
Osteoarthritis
destruction of articular cartilage
proliferation of contiguous bone
Degenerative joint disease
a name for OA
degenerative arthritis
a name for OA
degenerative arthrosis
is a normal degenerative condition associated with aging. It affects mainly
cartilage which becomes rugged, irregular and worn out.
Osteoarthrosis
another name for OA
Osteoarthritis Symptoms
Joint pain/inflammation
decreased joint mobility
bony spurs
Symptoms of OA
pain with use, improved with rest
stiffness
rarely before 40
lack of systematic symptoms
Signs of OA
joint tenderness
bony enlargement
crepitance
swelling
Heberden’s and Bouchard’s nodes
Bony enlargement in the inter-phalangeal joint (distal and proximal, respectively)
OA deformities
Heberden's and Bouchard's nodes Genu Varus Squaring of the 1st carpometacarpal joint Hallux valgus c/l spine spondylosis
Genu Varus
bow-legged
Hallux Valgus
big toe bunnion
spondylosis
Degenerative change
In all OA studies, the relationship to_______is striking.
aging
Which population has the most severe OA disease
Women. Aging is biggest risk factor
Primary OA
no known inciting event
Secondary OA
known event or disease caused the OA
The joint in OA is grossly characterized by:
cartilage irregularities and “fissuring”
hypertrophy of bone adjacent to the joint
Cartiallage consists of:
Collagen Proteoglycans Matrix Proteins Chrondrocytes Water
Chondrocytes
synthesize extracellualr components
Adipokines
cytokine produced by adipose tissue
low grade inflamation
Increases OA risk with obesity
Predisposing factors to OA
genetics metabolic abnormalities trama inflammatory joint disease Obesity Age
Blood tests for OA
aggrecan, keratin sulfate, and chondroitin sulfate; type II collagen, link protein, and osteocalcin; cartilage matrix glycoprotein, and cartilage oligomeric protein (COMP).
COMP appears the most promising.
OA treatment
metalloproteinase inhibitors, synthetic proteoglycans, and intra-articular injection of chelators to inhibit MMP.
OA Xray would show
Asymmetric loss of cartilage - Bone touching bone
Bony spurs- prolifferative bone
Subchondral sclerosis
Matrix metalloproteinases (MMPs)
collectively cleave most if not all of the constituents of the extracellular matrix.
Chondrocytes:
synthesize all of the important extracellular components
Proteoglycan
Collagen
