BL- Cohan 1 Flashcards
Th17
Makes interleukin 17, IL 17.
Causes very bad inflammation for toughest agents
Pro inflammatory
Th1 job
Delayed hypersensitivity
Attracts m1 macrophages
Release ifn gama
Th2
Helper T cell
Longer development than th1
Brings m2 macrophages (less angry than m1)
Can encourage fibrous capsule growth
Th2 fx and cytokine
Scarring
Attracts eosinophils
IL4
Tfh
Interacts with developing B cells to “switch”
Treg function
Helper cell
Tells all other helper cells to stop responding and making cytokines
“Wiser older sibling”
CTL name
Killer cell
Cytotoxic t lymphocyte
CD8 mhc class
Cd8 interacts with class one mhc
CD4 MHC Class
Cd4 interact with class two MHC
CD4 Is on what kind of cell
T helper
CD8 are on what cell
CTL
MHC Class two chains
Two chains, both bind. Alpha and beta
Class one MHC is on…
Every nucleated cell has class one MHC on their surface
CTL can see ____ cells
CTL can see All Cells. CTL sees class one MHC, and MHC is on all cells.
CLASS TWO MHC
Basics
T helper cells see class two. Three cells make class two
Dendritic
Macrophage
B Cells
Professional Antigen Presenting Cells
Dendritic
Macrophages
B cells
Class two MHC cells
B Cell MHC reaction with Tfh
Antigen binds B cell chops it up Presents peptide on MHC 2 Tfh interacts Tfh activates B cell
T Independent antigen
Usually carbs
Activates B cell with out T cell
B cell can only make IgM like this
HLA D cells
MHC Class 2 cells
Dendritic, macrophage, B cell
Hemosiderin
is most commonly found in macrophages and is especially abundant in situations following hemorrhage
Ankylosing spondylitis
Strong genetic inflammation activists with IL1
chronic inflammatory disease of the axial skeleton
involves CD8 T cells, which interact with HLA-B.
Natural, active immunity
usual immunity that results from real-life exposure to a pathogen.
Natural, passive immunity
fetus gets IgG
passively across the placenta from its mother
the baby gets IgA in mother’s milk if she nurses it
Artificial, active immunity
: immunity resulting from intentional immunization with vaccines, toxoids, or
other antigenic preparations.
Artificial, passive immunity
the use of immune serum or purified antibodies to protect a patient at risk
from a particular disease
tetanus, immunization offers close to _____ protection
100%
Cause of sherocytosis
Spleen notices membrane defect and pinches some off
Glucose-6-phosphate dehydrogenase deficiency
enzyme involved in the pentose phosphate pathway that is especially important in the red blood cell.
genetic condition that predisposes to hemolysis
Natural Killer cell activity is enhanced by
IL-2
C3b
opsonization
C3a, C5a
anaphylaxis
C5a
Neutriphil chemotaxis
C5b
Cytolysis by Mac
First antibody responder?
IgM
Second Antibody responder
IgG
Best compliment activator of the antibodies?
IgM
C1q complement needs to bind how many FCs
2 to activate
Coombs Test
detects antibodies that are already attached to red blood cells
Indirect Coombs Tets
detect very low concentrations of antibodies present in a patient’s plasma/serum prior to a blood transfusion.
