BL- IMMUNO REVIEW

Question 1

Murine

Answer 1

fully mouse monoclonal ab

one time use

Question 2

Chiamaric

Answer 2

mouse variable region

Humanized constant region

Question 3

Humanized mAB

Answer 3

Only has mouse CDR

Question 4

Fully humanzied example

Answer 4

Humaria

scid mouse w/ human immune system transplant made into human antibody

Question 5

Natural killer cells have 2 mechanisms:

Answer 5

ADCC- NK targets antibodies

DAMP/PAMP innate immunity

Question 6

Natural KIller cells are also called?

Answer 6

Large Granular Lymphocyte

Question 7

Universal Recipient blood type

Answer 7

AB Rh(D)

Question 8

Direct Antigen vs, Indirect Antigen tests

Answer 8

Direct: tests for AB bound to cell (ex: rbc)

Indirect: Tests for AB in pt serum

Question 9

Rhogram _______ immunization

Answer 9

Prevent

Works in Rh- mothers

Question 10

Can you immunize against ABO

Answer 10

No, exposure occurs in infancy

Question 11

Hemolytic disease of the newborn

Answer 11

an alloimmune condition that develops in a fetus, when the IgG molecules produced by the mother pass through the placenta.
Among these antibodies are some which attack the red blood cells in the fetal circulation

Question 12

Elisa tests for?

Answer 12

Antibody in the patients serum

Question 13

Capture Elisa tests for?

Answer 13

Antigen in pts serum

Question 14

What is the best T cell Test?

Answer 14

Skin test (ex: TB)

Question 15

Proteins to be aware of in HIV

Answer 15

CD4- on t cell
CCR5- co receptor

gp120, gp41 on HIV

Question 16

If MHC decreases, then NK cells ____ in response to tumors

Answer 16

Increase

Question 17

BRAF mutation is present in?

Answer 17

melenoma

Question 18

BCC has a mutation in?

Answer 18

hedgehog/smoothened