BL- VASCULITIS Flashcards
Rheumatoid arthritis (RA) begins with inflammation in which structure/tissue?
Synovium
Clinical presentations of this type of vasculitis include temporal headache, jaw claudication, scalp tenderness, and vision loss
Giant cell arteritis
Typical histology of small vessel vasculitis:
Leukocytoclastic vasculitis
Cytoplasmic –ANCA (c-ANCA) is common to Wegener’s granulomatosis as perinuclear-ANCA (p-ANCA) is common to:
microscopic polyangiitis (MPA)
examples of immune complex (IC)-induced vasculitis
Hepatitis B-associated vasculitis
Cryoglobulinemic vasculitis
Henoch-Schönlein purpura
Hypersensitivity vasculitis (cutaneous leukocytoclastic angiitis)
suspected immunopathogenic mechanisms that mediate vasculitis
Infection of endothelial cells
Immune complexes (IC)
T cell dependent mediated endothelial cell injury
Autoantibodies such as ANCAs and antiendothelial antibodies
Immune complexes (IC)
Vasculitides are a rare group of disorders defined by the size of the vessel involved, the pathologic change in the vessel wall, and the:
clinical presentation
In primary vasculitis, the inciting agent is unknown. The vasculitic response may be due to IC deposition, autoantibodies (anti-endothelial, ANCAs), antigen-driven inflammation, and/or infection of: ______
endothelial cells
heterogeneous group of clinical disorders characterized by inflammation of blood vessels
vasculitides
Vasculitides can be primary or ____ to infectious disorders, drug hypersensitivity, connective tissue diseases, cryoglobulins, and malignancies.
secondary
Large-vessel vasculitis
Giant cell arteritis
Takayasu’s arteritis
Medium-vessel vasculitis
Polyarteritis nodosa
Kawasaki’s disease
Small-vessel vasculitis
(ANCA) positive vasculitides:
Granulomatosis with polyangiitis (Wegener’s)
Eosinophilic granulomatosis with polyangiitis
Microscopic polyangiitis (MPA
Small-vessel vasculitis
(ANCA) negative vasculitides:
Essential cryoglobulinemic vasculitis
Cutaneous leukocytoclastic angiitis
Henoch-Schönlein Purpura (HSP):
vasculitis Labs
anemia of inflammatory disease thrombocytosis low albumin elevated sed rate/crp polyclonal gammopathy
aortic arch and its branches, can involve any part of the aorta; claudication of upper > lower extremities, CNS events; granulomatous panarteritis
Takayasu’s arteritis
temporal arteries
vessels originating from the aortic arch
headache, jaw claudication, scalp tenderness, visual loss;
Giant cell arteritis
small/medium arteries; may affect any organ, but skin, joints, peripheral nerves, gut, and kidney are most commonly involved;
necrotizing arteritis
involvement at the vessel bifurcation
***Polyarteritis nodosa
Wegener’s Granulomatosis
systemic disorder that involves both granulomatosis and polyangiitis. It is a form of vasculitis (inflammation of blood vessels) that affects small- and medium-size vessels in many organs.
Cytoplasmic –ANCA (c-ANCA) is common to Wegener’s granulomatosis as perinuclear-ANCA (p-ANCA) is common to ______ (MPA)*
microscopic polyangiitis
**C-ANCA often binds to
proteinase 3 (PR3) found in the primary granules of neutrophils
**P-ANCA often binds to
myeloperoxidase (MPO) found in primary granules of neutrophils
plasmapheresis______ beneficial in ANCA-positive vasculitides
IS
AFTER treatment of vasculitis high risk of
Atherosclerosis
