BL- VASCULITIS

Question 1

Rheumatoid arthritis (RA) begins with inflammation in which structure/tissue?

Answer 1

Synovium

Question 2

Clinical presentations of this type of vasculitis include temporal headache, jaw claudication, scalp tenderness, and vision loss

Answer 2

Giant cell arteritis

Question 3

Typical histology of small vessel vasculitis:

Answer 3

Leukocytoclastic vasculitis

Question 4

Cytoplasmic –ANCA (c-ANCA) is common to Wegener’s granulomatosis as perinuclear-ANCA (p-ANCA) is common to:

Answer 4

microscopic polyangiitis (MPA)

Question 5

examples of immune complex (IC)-induced vasculitis

Answer 5

Hepatitis B-associated vasculitis

Cryoglobulinemic vasculitis

Henoch-Schönlein purpura

Hypersensitivity vasculitis (cutaneous leukocytoclastic angiitis)

Question 6

suspected immunopathogenic mechanisms that mediate vasculitis

Answer 6

Infection of endothelial cells

Immune complexes (IC)

T cell dependent mediated endothelial cell injury

Autoantibodies such as ANCAs and antiendothelial antibodies

Immune complexes (IC)

Question 7

Vasculitides are a rare group of disorders defined by the size of the vessel involved, the pathologic change in the vessel wall, and the:

Answer 7

clinical presentation

Question 8

In primary vasculitis, the inciting agent is unknown. The vasculitic response may be due to IC deposition, autoantibodies (anti-endothelial, ANCAs), antigen-driven inflammation, and/or infection of: ______

Answer 8

endothelial cells

Question 9

heterogeneous group of clinical disorders characterized by inflammation of blood vessels

Answer 9

vasculitides

Question 10

Vasculitides can be primary or ____ to infectious disorders, drug hypersensitivity, connective tissue diseases, cryoglobulins, and malignancies.

Answer 10

secondary

Question 11

Large-vessel vasculitis

Answer 11

Giant cell arteritis

Takayasu’s arteritis

Question 12

Medium-vessel vasculitis

Answer 12

Polyarteritis nodosa

Kawasaki’s disease

Question 13

Small-vessel vasculitis

(ANCA) positive vasculitides:

Answer 13

Granulomatosis with polyangiitis (Wegener’s)
Eosinophilic granulomatosis with polyangiitis
Microscopic polyangiitis (MPA

Question 14

Small-vessel vasculitis

(ANCA) negative vasculitides:

Answer 14

Essential cryoglobulinemic vasculitis
Cutaneous leukocytoclastic angiitis
Henoch-Schönlein Purpura (HSP):

Question 15

vasculitis Labs

Answer 15

anemia of inflammatory disease
 thrombocytosis
low albumin
elevated sed rate/crp
polyclonal gammopathy

Question 16

aortic arch and its branches, can involve any part of the aorta; claudication of upper > lower extremities, CNS events; granulomatous panarteritis

Answer 16

Takayasu’s arteritis

Question 17

temporal arteries
vessels originating from the aortic arch

headache, jaw claudication, scalp tenderness, visual loss;

Answer 17

Giant cell arteritis

Question 18

small/medium arteries; may affect any organ, but skin, joints, peripheral nerves, gut, and kidney are most commonly involved;
necrotizing arteritis
involvement at the vessel bifurcation

Answer 18

***Polyarteritis nodosa

Question 19

Wegener’s Granulomatosis

Answer 19

systemic disorder that involves both granulomatosis and polyangiitis. It is a form of vasculitis (inflammation of blood vessels) that affects small- and medium-size vessels in many organs.

Question 20

Cytoplasmic –ANCA (c-ANCA) is common to Wegener’s granulomatosis as perinuclear-ANCA (p-ANCA) is common to ______ (MPA)*

Answer 20

microscopic polyangiitis

Question 21

**C-ANCA often binds to

Answer 21

proteinase 3 (PR3) found in the primary granules of neutrophils

Question 22

**P-ANCA often binds to

Answer 22

myeloperoxidase (MPO) found in primary granules of neutrophils

Question 23

plasmapheresis______ beneficial in ANCA-positive vasculitides

Answer 23

IS

Question 24

AFTER treatment of vasculitis high risk of

Answer 24

Atherosclerosis

Question 25

Hepatitis B virus infection is associated with ______

Answer 25

Polyarteritis nodosa**

Question 26

Complement decreases in disorders with circulating ______

Answer 26

Immune Complexes

Question 27

_____are antibodies to antigens found in the cytoplasm of neutrophils.

Answer 27

ANCA

Antineutrophil Cytoplasmic Antibodies

Question 28

ABs can damage endothelial cells by both antibody-dependent cellular cytotoxicity (ADCC) and complement activation mechanisms.

these ABs directed toward structures on the surface of endothelial cells are NOT found in all vasculitic syndromes.

Answer 28

Antiendothelial antibodies:

Question 29

antigen-driven vascular inflammation. This polymorphism is not shared by patients with rheumatoid arthritis.

Answer 29

T Cell Dependent Mediated Endothelial Cell Injury

Question 30

promote binding of IC and PMNs, express MHC class II genes, enhance local lymphocyte proliferation, and release stimulatory and proliferative cytokines.

These changes may promote the vascular inflammatory response and initiate a T cell proliferative response.

Answer 30

Infection of Endothelial Cells

Question 31

Vasculitis can affect vessels _____

Answer 31

Anywhere

Question 32

Fever
HA
tenderness on side of head
Older person

Answer 32

Giant Cell