BL- PM/DM Flashcards
The erythematous papular rash over the metacarpal or interphalangeal joints that classically occurs in dermatomyositis is known as:
Gottron’s papules
features of the Anti-synthetase Syndrome
Arthritis
Raynaud’s phenomenon
Interstitial lung disease
Mechanic’s hands
The anti-synthetase antibody, anti-Jo-1, is directed against which aminoacyl-tRNA synthetase?
Histidyl
**In polymyositis, the muscle inflammatory cell infiltrate is primarily which cell type:
CD8+ T cells
In autoimmune inflammatory myopathies, which laboratory test is elevated in the vast majority of patients with active disease:
Creatine phosphokinase (CPK)
DM/PM: Rare autoimmune muscle diseases characterized by _____; other organs may be involved.
symmetric proximal muscle weakness
Polymyositis (PM) and dermatomyositis (DM) are the most common of the rare….
autoimmune inflammatory muscle diseases
PM/DM my also show signs of
inflammatory arthritis rash Raynaud’s phenomenon interstitial lung disease myositis-specific antibodies in the anti-synthetase syndrome
Elevated levels of serum muscle enzymes (CPK) are present and _____ reveal myopathic findings
Electromyography
**endomysial distribution; appears to be a direct CD8+ T cell-mediated muscle injury
Polymyositis
**perivascular distribution; CD4+ T cells; perifascicular atrophy; considered in part to be a complement-mediated vasculopathy. There may also be a central role for type I interferons
dermatomyositis
DM/PM Treatment is directed at suppressing the:
autoimmune inflammatory response
In DM/PM, characterized by chronic muscle weakness and infiltration of muscle tissue by
chronic inflammatory cells
Reynolds Phenomena
whiteness/blue in hands
excessively reduced blood flow in response to cold or emotional stress, causing discoloration of the fingers, toes, and occasionally other areas.
Inclusion Body Myositis**
inflammatory myopathies, which are characterized by chronic, progressive muscle inflammation accompanied by muscle weakness.
rimmed vacules and inclusions
