BL- Introduction to Hemostasis

Question 1

Pro teases of the clotting path way are

Answer 1

Prekallikrein
12
11
9
7
10
2
13*

*=not serine

Question 2

Factor X is at _____

Answer 2

the cross roads

Question 3

Factor XIII-
A transglutaminase: forms amide bonds between specific lysine and glutamine residues of fibrin to make a stable____

Answer 3

clot

Question 4

Cofactors of the clotting path way are

Answer 4

HMWK
TF
VIII
V

These speed up the reaction

Question 5

Prekallikrein
12
11
9
7
10
2
13
These are all

Answer 5

Proteases

Question 6

Lack intrinsic enzymatic activity

Act as receptors for other components of enzyme complexes, to speed reactions several hundred to several thousand-fold

Answer 6

Cofactors

Question 7

Fibrinogen of the clotting path way are

Answer 7

Factor I (Fibrin)
*makes the actual clot

Question 8

HMWK
TF
VIII
V
are?

Answer 8

Cofactors

Question 9

_______requires the interaction of platelets, coagulation and fibrinolytic factors, endothelium, proinflammatory and anti-inflammatory mediators, and leukocytes

Answer 9

Hemostasis

Question 10

Clot formation is typically initiated by vascular injury, in which a platelet plug forms and is reinforced with ______ produced via the extrinsic pathway

Answer 10

fibrin

Question 11

Coagulation Factors 1

Answer 11

I Fibrinogen

Question 12

Cofactors

Answer 12

Lack intrinsic enzymatic activity

Act as receptors for other components of enzyme complexes, to speed reactions several hundred to several thousand-fold

Question 13

Coagulation Factors 2

Answer 13

II Prothrombin

Question 14

Coagulation Factors 3

Answer 14

III Thromboplastin

Question 15

Coagulation Factors 5

Answer 15

Proaccelerin

Question 16

Coagulation Factors 7

Answer 16

Proconvertin

Question 17

Coagulation Factors 8

Answer 17

Antihemophilic

Question 18

Coagulation Factors 9

Answer 18

Christmas

Question 19

Coagulation Factors 11

Answer 19

Plasma thromboplastin antecedent

Question 20

Coagulation Factors 13

Answer 20

Fibrin stabilizing

Question 21

Coagulation Factors IV

Answer 21

Calcium

Question 22

Prothrombin + Thromboplastin + Calcium = Thrombin

Fibrinogen + Thrombin = Fibrin

Answer 22

Two-step process of coagulation:

Question 23

The Prothrombin time

Answer 23

measures of prothrombin ratio (PR) and international normalized ratio (INR) are measures of the extrinsic pathway of coagulation. This test is also called “ProTime INR”

Question 24

Almost all blood factors are made in the:

Answer 24

liver

If this isn’t functioning well, you become coagulopathic

Question 25

blood factors NOT made by the liver

Answer 25

Tissue factor Factor VIII Von Willebrand factor

Question 26

Two-step process of coagulation:

Answer 26

Prothrombin + Thromboplastin + Calcium = Thrombin Fibrinogen + Thrombin = Fibrin

Question 27

Biliary obstruction leads to vitamin K deficiency due to

Answer 27

fat malabsorption

Question 28

Vitamin K eventually isolated as the factor needed to ______ the bleeding problem

Answer 28

prevent “K” for “Koagulation”

Question 29

Vitamin K dependent factors

Answer 29

``` Factor IX Factor VII Factor X Factor II (Thrombin) Protein C, Protein S ```

Question 30

Reasons newborns are prone to develop Hemorrhagic disease of the newborn

Answer 30

Vitamin K deficiency ~Decreased stores ~Low levels in breast milk ~Developing gut flora

Question 31

Vitamin K required for _________ of several coagulation proteins in the liver

Answer 31

post translational modification

Question 32

PT test is useful for

Answer 32

Coagulopathy associated with jaundice | Hemorrhagic disease of the newborn

Question 33

``` Factor IX Factor VII Factor X Factor II (Thrombin) Protein C, Protein S these are all? ```

Answer 33

Vitamin K dependent factors | Factors II, VII, IX, X, Protein C, Protein S

Question 34

Coagulopathy associated with jaundice | Hemorrhagic disease of the newborn

Answer 34

PT test useful

Question 35

The Activated Partial Thromboplastin time (APTT)

Answer 35

activated partial thromboplastin time characterizes blood coagulation. PTT is a performance indicator of the efficacy of both the "intrinsic" (now referred to as the contact activation pathway) and the common coagulation pathways. It is used in conjunction with the prothrombin time (PT) which measures the extrinsic pathway

Question 36

Vitamin K dependent factors are located?

Answer 36

Centrally in the pathway (around 10)

Question 37

PT is a problem in ______ pts

Answer 37

hemophiliac patients

Question 38

hemophiliac patients are deficient in

Answer 38

factor 13 (a) or 9 (b)

Question 39

Vitamin K dependent factors

Answer 39

Factors II, VII, IX, X, Protein C, Protein S

Question 40

Use of the _____led to discovery of the intrinsic pathway factors

Answer 40

APTT

Question 41

Deficiency of __________ not associated with bleeding

Answer 41

Prekallikrein Factor XII HMWK

Question 42

Coagulation occurs in three phases

Answer 42

Initiation Amplification Propagation

Question 43

Abnormal factors in the _____ pathway will lead to an abnormal ATPP

Answer 43

intrinsic

Question 44

Initiation steps (1)

Answer 44

Tissue Factor exposed Factor 7a binds TF Binds Factor 10 (extrinic tenase)-->10a Factor 9 can also be activated

Question 45

extrinic tenase activates

Answer 45

factors 9 and 10

Question 46

Initiation steps (2)

Answer 46

10a binds-->5a binds-->factor 2 OR 10a binds --> 2 2 leads to 2a leads to amplification

Question 47

2 leads to 2a leads to:

Answer 47

amplification

Question 48

Thrombin (2) activates

Answer 48

Factor 11* important and Factor XIa VIIIa Va