PATHOMA- Derm inflam Flashcards
Layers of the Epidermis
top to bottome
Corneum Lucidum Granulosum Spinosum Basale ~BM~ Dermis
Stratum corneum contains?
Keratin
Stratum spinosum contains?
Desmosomes
a cell structure specialized for cell-to-cell adhesion. A type of junctional complex, they are localized spot-like adhesions randomly arranged on the lateral sides of plasma membranes.
Desmosomes
key structural material making up the outer layer of human skin. It is also the key structural component of hair and nails.
Keratin
The dermis contains
adnexal structures Blood vessels sweat glands sebaceous glands connective tissue
sebaceous glands
microscopic exocrine glands in the skin that secrete an oily or waxy matter, called sebum, to lubricate and waterproof the skin and hair of mammals
The basal cells functions to
Stem cell layer
Creates new epidermis
An itchy inflammation of the skin
also known as atopic eczema or eczema
Atopic dermatitis
Dermatitis means
inflammation of the skin
Atopic dermatitis key points
s/s pruitic erthemitic oozing vesicles edema
face/flexor
rx: topical steroids
results from exposure to allergens or irritants
Contact dermatitis
caused by chemical irritants and those caused by physical irritants.
irritant contact dermatitis
manifestation of an allergic response caused by contact with a substance
allergic contact dermatitis
Common irritants in irritant contact dermatitis
nickel
poison ivy
detergents
drugs
rx: remove irritant from exposure
Topical steriods
chronic inflammation of hair follicle and sebacous glands
acne vulgaris
acne vulgaris is caused by?
Hormones leading to increased sebum
excess keratin
*blocked follicle leading to infection by p. acne
Inflammation in Acne is the result of?
lipase breaks down xs sebum
release of inflammatory mediators
chronic, relapsing/remitting, immune-mediated systemic disease characterized by skin lesions including red, scaly patches, papules, and plaques, which usually itch.
Psoriasis
Psoriasis lesions are?
well circumscribed
salmon colored
silver scales
also shows nail pitting
Psoriasis are located?
extensor surfaces
scalp
Psoriasis is caused by?
possibly autoimmune
excess keratinocytes
HLA-C ass.
diffuse epidermal hyperplasia (thickening of the skin).
Acanthosis
Cellulitis morphology
warm, tender, red, patch, plaque
Cellultisis loction
dermis/sub q tissue
Dermatitis location
epidermis/ dermis
infection of the upper dermis and superficial lymphatics, usually caused by streptococcus bacteria on scratches or otherwise infected areas
Erysipelas
rysipelas is more superficial than cellulitis, and is typically more raised and _______
demarcated.
Erysipelas location
dermis
minimal sub q
Stasis dermis location?
lower leg
Seborrheic dermatitis location?
scalp
Atopic dermatitis location?
flexor
Psoriasis location?
extensor
*may have arthritis
Lower ext. edema
statis dermatitis
Malassezia furfur
Seborrheic dermatitis
Malassezia is a genus of fungi. Malassezia is naturally found on the:______
skin surfaces
Filaggrin
a filament-associated protein that binds to keratin fibers in epithelial cells.
Atopic derm etiology
Filaggrin etiology
Atopic derm is ass w/?
asthma
alleric rhinitis
Allergic contact derm is a _____ rxn
Delayed hypersensitivity
Allergic contact derm is confirmed by?
patch testing
______ may be ass. w/ cardiovascular disease
Psoriasis
Prurtic Planar Polygonal Purple Papule
Lichen Planus
HEP C related inflammatory rash
Lichen Planus
