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BL/DD USMLE and Basics > PATHOMA- Derm inflam > Flashcards

PATHOMA- Derm inflam Flashcards

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USMLE® Step 1 flashcards
1
Q

Layers of the Epidermis

top to bottome

A 
Corneum
Lucidum
Granulosum
Spinosum
Basale
~BM~
Dermis
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2
Q

Stratum corneum contains?

A

Keratin

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3
Q

Stratum spinosum contains?

A

Desmosomes

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4
Q

a cell structure specialized for cell-to-cell adhesion. A type of junctional complex, they are localized spot-like adhesions randomly arranged on the lateral sides of plasma membranes.

A

Desmosomes

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5
Q

key structural material making up the outer layer of human skin. It is also the key structural component of hair and nails.

A

Keratin

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6
Q

The dermis contains

A 
adnexal structures 
Blood vessels
sweat glands 
sebaceous  glands 
connective tissue
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7
Q

sebaceous glands

A

microscopic exocrine glands in the skin that secrete an oily or waxy matter, called sebum, to lubricate and waterproof the skin and hair of mammals

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8
Q

The basal cells functions to

A

Stem cell layer

Creates new epidermis

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9
Q

An itchy inflammation of the skin

also known as atopic eczema or eczema

A

Atopic dermatitis

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10
Q

Dermatitis means

A

inflammation of the skin

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11
Q

Atopic dermatitis key points

A 
s/s
pruitic 
erthemitic 
oozing
vesicles
edema

face/flexor
rx: topical steroids

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12
Q

results from exposure to allergens or irritants

A

Contact dermatitis

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13
Q

caused by chemical irritants and those caused by physical irritants.

A

irritant contact dermatitis

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14
Q

manifestation of an allergic response caused by contact with a substance

A

allergic contact dermatitis

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15
Q

Common irritants in irritant contact dermatitis

A

nickel
poison ivy
detergents
drugs

rx: remove irritant from exposure
Topical steriods

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16
Q

chronic inflammation of hair follicle and sebacous glands

A

acne vulgaris

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17
Q

acne vulgaris is caused by?

A

Hormones leading to increased sebum
excess keratin
*blocked follicle leading to infection by p. acne

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18
Q

Inflammation in Acne is the result of?

A

lipase breaks down xs sebum

release of inflammatory mediators

19
Q

chronic, relapsing/remitting, immune-mediated systemic disease characterized by skin lesions including red, scaly patches, papules, and plaques, which usually itch.

A

Psoriasis

20
Q

Psoriasis lesions are?

A

well circumscribed
salmon colored
silver scales

also shows nail pitting

21
Q

Psoriasis are located?

A

extensor surfaces

scalp

22
Q

Psoriasis is caused by?

A

possibly autoimmune
excess keratinocytes
HLA-C ass.

23
Q

diffuse epidermal hyperplasia (thickening of the skin).

A

Acanthosis

24
Q

Cellulitis morphology

A

warm, tender, red, patch, plaque

25
Q

Cellultisis loction

A

dermis/sub q tissue

26
Q

Dermatitis location

A

epidermis/ dermis

27
Q

infection of the upper dermis and superficial lymphatics, usually caused by streptococcus bacteria on scratches or otherwise infected areas

A

Erysipelas

28
Q

rysipelas is more superficial than cellulitis, and is typically more raised and _______

A

demarcated.

29
Q

Erysipelas location

A

dermis

minimal sub q

30
Q

Stasis dermis location?

A

lower leg

31
Q

Seborrheic dermatitis location?

A

scalp

32
Q

Atopic dermatitis location?

A

flexor

33
Q

Psoriasis location?

A

extensor

*may have arthritis

34
Q

Lower ext. edema

A

statis dermatitis

35
Q

Malassezia furfur

A

Seborrheic dermatitis

36
Q

Malassezia is a genus of fungi. Malassezia is naturally found on the:______

A

skin surfaces

37
Q

Filaggrin

A

a filament-associated protein that binds to keratin fibers in epithelial cells.

38
Q

Atopic derm etiology

A

Filaggrin etiology

39
Q

Atopic derm is ass w/?

A

asthma

alleric rhinitis

40
Q

Allergic contact derm is a _____ rxn

A

Delayed hypersensitivity

41
Q

Allergic contact derm is confirmed by?

A

patch testing

42
Q

______ may be ass. w/ cardiovascular disease

A

Psoriasis

43
Q 
Prurtic 
Planar
Polygonal 
Purple 
Papule
A

Lichen Planus

44
Q

HEP C related inflammatory rash

A

Lichen Planus

BL/DD USMLE and Basics (55 decks)

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