P8 - Erythrocytes Part 3

Question 1

MCV

Answer 1

• mean cell volume

Question 2

MCHC

Answer 2

• average [Hgb] in RBC

Question 3

MCH

Answer 3

• average Hgb content in RBCs

Question 4

reticulocyte concentration is the best value to determine

Answer 4

• regenerative or nonregenerative anemia

Question 5

anemia if reticulocytes are present

Answer 5

• regenerative

Question 6

anemia if reticulocytes are not present

Answer 6

• nonregenerative

Question 7

disorders and conditions that cause nonregenerative anemia

Answer 7

• inflammatory disease
• renal disease
• disease causing marrow hypoplasia or aplasia
• disease causing erythroid hypoplasia or ineffective erythropoiesis

Question 8

disorders and conditions that cause regenerative anemia

Answer 8

• blood loss

- hemolytic

Question 9

inflammatory disease pathogenesis to cause nonregenerative anemia

Answer 9

• cytokines cause erythroid cells to be less responsive to EPO -> decrease RBC production
• cytokines shift Fe to storage -> less Fe for erythropoiesis

Question 10

renal disease pathogenesis to cause nonregenerative anemia

Answer 10

• decreased EPO production -> decrease RBC production

- decreased clearing of metabolic waster from plasma

Question 11

acute (internal and external) blood loss pathogenesis to cause regenerative anemia

Answer 11

• hypovolemia -> shift of H20 from extra to intravascular -> hemodilution

Question 12

chronic (external) blood loss pathogenesis to cause regenerative anemia

Answer 12

• depletion of Fe stores -> erythroid precursors less responsive to EPO
• defective Hgb synthesis -> production of RBC with low [Hgb]
• microcytic hypochromic or normochromic anemia

Question 13

spun (sHct) and calculated (cHct) should agree within what percentage

Answer 13

• 3%

Question 14

ruminants only have reticulocytes if

Answer 14

• there is an extreme challenge