P23 - Cytologic Biopsy of RCN and Lymph Nodes

Question 1

nucleated cellularity of round cell neoplasms

Answer 1

• high (hypercellular)

Question 2

cell arrangement of round cell neoplasms

Answer 2

• non-epithelioid (individual)

Question 3

morphology of round cell neoplasms

Answer 3

• round cell and nuclei

Question 4

cell boundaries of round cell neoplasms

Answer 4

• distinct

Question 5

round cell neoplasms with cytoplasmic granules

Answer 5

• mast cell tumors

- melanoma

Question 6

mast cell tumors cytoplasm

Answer 6

• pink or reddish purple granules

Question 7

stains for mast cell tumors

Answer 7

• toluidine blue

Question 8

melanoma cytoplasm

Answer 8

• green-black granules

Question 9

melanomas located in inter-digital and mouth are considered benign or malignant

Answer 9

• malignant

Question 10

transmissible venereal tumor cytoplasm

Answer 10

• aggregates of vacuoles

- basophilic

Question 11

histiocytoma cytoplasm

Answer 11

• pale clear

- no vacuoles

Question 12

lymphoma cytoplasm

Answer 12

• high N:C ratio

- basophilic

Question 13

plasmacytoma cytoplasm

Answer 13

• deeply basophilic

- eccentrically-placed nucleus

Question 14

nucleated cellularity of neoplasms of epithelial origin

Answer 14

• high

- hypercellular

Question 15

cell arrangement of neoplasms of epithelial origin

Answer 15

• epitheloid

- clusters/sheets

Question 16

morphology of neoplasms of epithelial origin

Answer 16

• round to polyhedral

Question 17

cell boundaries of neoplasms of epithelial origin

Answer 17

• distinct

Question 18

examples of benign neoplasms of epithelial origin

Answer 18

• glandular - thyroid adenoma

- lining epithelium - papilloma

Question 19

examples of malignant neoplasms of epithelial origin

Answer 19

• glandular - mammary adenocarcinoma

- lining epithelium - squamous cell carcinoma

Question 20

nucleated cellularity of neoplasms of mesenchymal origin

Answer 20

• low

- hypocellular

Question 21

cell arrangement of neoplasms of mesenchymal origin

Answer 21

• non-epitheloid

- individual

Question 22

morphology of neoplasms of mesenchymal origin

Answer 22

• spindle with tails

Question 23

cell boundaries of neoplasms of mesenchymal origin

Answer 23

• indistinct

Question 24

examples of benign neoplasms of mesenchymal origin

Answer 24

• fibroma

- leiomyoma

Question 25

examples of malignant neoplasms of mesenchymal origin

Answer 25

• fibrosarcoma
• osteosarcoma
• myxosarcoma

Question 26

5 categories of lymphadenopathy

Answer 26

• normal
• hyperplastic
• lymphadenitis
• lymphoma
• metastasis to lymph nodes

Question 27

hyperplastic (reactive) lymph node

Answer 27

• enlarged

- cytological similar to normal

Question 28

inflammation of LN (lymphadenitis) characterized by

Answer 28

• infiltration of LN by many neutrophils

Question 29

lymphoma (lymphosarcoma) characterized by

Answer 29

• monomorphism

Question 30

stage 1 lymphoma

Answer 30

• single LN involved

Question 31

stage 2 lymphoma

Answer 31

• multiple regional LN

Question 32

stage 3 lymphoma

Answer 32

• generalized lndeopathy

Question 33

stage 4 lymphoma

Answer 33

• stage 3 + liver and spleen

Question 34

stage 5 lymphoma

Answer 34

• involves bone marrow

Question 35

lymphoma originates in

Answer 35

• lymph nodes

Question 36

leukemia originates in

Answer 36

• bone marrow

Question 37

further diagnostics are necessary to subtype lymphomas (4)

Answer 37

• different subtypes have different behavior
• flow cytometry identifies different CD surface proteins cells
• PCR for antigen receptor rearrangements (PARR)
• karyotyping involved detection of abnormal chromatin patterns

Question 38

lymphoma that responds well to chemotherapy

- have CD79a molecules

Answer 38

• B-cell

Question 39

lymphoma that has a bad prognosis

- have CD3 molecules

Answer 39

• T-cell