P12 - Leukocytes Part 2

Question 1

factors that alter [neutrophils]associated with inflammation (4)

Answer 1

• severity of inflammation in tissues
• which tissues inflamed
• duration of inflammation
• species (dogs>cat>horse>cattle)

Question 2

acute inflammatory pathogenesis (with left shift)

Answer 2

• macrophages and lymphocytes release cytokines
• cytokines stimulate release from storage pool -> neutrophilia
• cytokines stimulate release from maturation pool -> left shift
• cytokines stimulate production of neutrophils

Question 3

chronic inflammatory pathogenesis

Answer 3

• macrophages and lymphocytes release cytokines
• cytokines stimulate production of neutrophils
• granulocytic hyperplasia (replinished storage pool)
• increase production and release of segmented neutrophils

Question 4

steroid use pathogenesis

Answer 4

• down regulation of adhesion protein in vessels -> shift neutrophils from marginating to circulating pool
• decrease neutrophils in tissues -> increase life span in blood

Question 5

physiologic shift pathogenesis

Answer 5

• fight or flight stimulus -> increase catecholamine
• down regulation of adhesion protein in vessels -> shift neutrophils from marginating to circulating pool
• increase blood flow rate through vessels -> shift neutrophils from marginating to circulating pool

Question 6

major types of neutrophilias (4)

Answer 6

• acute inflammatory (with left shift)
• chronic inflammatory (little to no left shift)
• steroid (little to no left shift - maybe right)
• physiologic (shift) (no left shift)