P16 - Platelets Flashcards
1
Q
platelet production in
A
- marrow
2
Q
typical amount of platelets
A
- 1/10 to 30 RBCs
3
Q
giant platelets are common finding in
A
- healthy cats
4
Q
giant platelets diameter
A
- larger than erythrocyte diameter
5
Q
thrombocytopenia
A
- platelet concentration is lower than reference interval
6
Q
major pathogenesis of thrombocytopenia (6)
A
- pseudothrombocytopenia
- decreased production
- decreased survival
- hemodilution
- abnormal distribution (sequestration)
- idiopathic or multifactorial
7
Q
pathogenesis of immune-mediated thrombocytopenia
A
- formation of anti-platelet antibodies
- antibodies bind to platelets -> macrophages engulf
8
Q
pathogenesis of consumptive thrombocytopenia
A
- damage to endothelium or activation of coagulation cascade -> activation of platelets
- aggregation and recruitment of platelets -> removed from blood
9
Q
pathogenesis of infectious canine cyclin thrombocytopenia
A
- immune-mediated destruction or sequestration
10
Q
thrombocytosis
A
- platelet concentration > reference interval
11
Q
pathogenesis of thromocytosis (3)
A
- increase production (inflammatory Fe deficiency)
- clonal (neoplasia)
- redistribution (exercise excitement)
12
Q
pseudothrombocytopenia caused by
A
- platelet clumps
- giant platelets
13
Q
species with lower platelet concentration
A
- horses
14
Q
impedance method
A
- leas to pseudothrombocytopenia in cats because their platelet are large
15
Q
giant platelets due to genetic variations in
A
- cavalier king charles spaniels
