P11 - Erythrocytes Part 5

Question 1

erythrocytosis

Answer 1

• increase RBC mass

Question 2

erythrocytosis pathogenesis (4)

Answer 2

• hemoconcentration
• excitement, fright, exercise -> splenic contraction
• cardiovascular or chronic respiratory disease
• neoplastic transformation

Question 3

hemoconcentration

Answer 3

• increase concentration of blood components because of decrease plasma volume

Question 4

polycythemia vera

Answer 4

• bone marrow kicks out too many red cells

Question 5

abnormalities in iron disorders

Answer 5

• hypoferremia
• hypoferritinemia
• hyperferritinemia

Question 6

hypoferremia

Answer 6

• decrease [iron] in serum or plasma

Question 7

hypoferremia pathogenesis (2 situations)

Answer 7

• persistent low grade blood loss -> stored Fe used to produce more Hgb for RBC
• persistent inflammatory disease (cytokines IL-6) -> Fe stays in macrophages -> hypoferremia

Question 8

hypoferritinemia

Answer 8

• decrease [ferritin] in serum or plasma

Question 9

hyperferritinemia

Answer 9

• increase [ferritin] in serum or plasma

Question 10

hypoxia stimulates production of what

Answer 10

• Epo

Question 11

In Fe deficiency trends of serum [Fe], stainable Fe in marrow, serum [ferritin]

Answer 11

• serum [Fe] -> decrease
• stainable Fe in marrow -> decrease
• serum [ferritin] -> decrease

Question 12

inflammation trends of serum [Fe], stainable Fe in marrow, serum [ferritin]

Answer 12

• serum [Fe] -> decrease
• stainable Fe in marrow -> increase
• serum [ferritin] -> increase