P41 - Exocrine Pancreas and Intestine

Question 1

enzymes provided in pancreatic secretions (3)

Answer 1

• proteins
• starches and complex sugars
• triglycerides

Question 2

maldigestion

Answer 2

• incomplete digestion of food

Question 3

malabsorption

Answer 3

• impaired intestinal absorption of nutrients

Question 4

• exocrine pancreatic insufficiency
• impaired bile acid delivery to intestine
  can lead to maldigestion or malabsorption

Answer 4

• maldigestion

Question 5

• mucosal abnormalities
• lymphatic obstruction
  can lead to maldigestion or malabsorption

Answer 5

• malabsorption

Question 6

pancreatic acinar cell atrophy (juvenile atrophy) is common in what breeds

Answer 6

• german shepherds

- rough-coated collie

Question 7

what 2 types of deficiency can lead to intestinal malabsorption and no weight loss

Answer 7

• cobalamin deficiency

- folate deficiency

Question 8

trypsin-like immunoreactivity (TLI) concentration is released from ____ and cleared by ____ and _____

Answer 8

• pancreatic acinar cells
• kidney
• macrophages

Question 9

in dogs, increase [TLI] tend to parallel increase in serum ___ and ____ activities

Answer 9

• AMS

- LPS

Question 10

immune-mediated atrophic lymphocytic pancreatitis (in GSD and rough-coated collies) can cause ____ in [TLI]

Answer 10

• decrease

Question 11

sensitivity of TLI and EPI in dogs

Answer 11

• 100%

Question 12

pancreatic lipase immunoreactivity (PLI) concentration is released from ____ and cleared by ____

Answer 12

• pancreatic acinar cells

- kidneys

Question 13

sensitivity of [PLI] in dogs indicating pancreatitis (increase release)

Answer 13

• 80-100%

Question 14

for canine cases: trying to detect current damage to acinar cells look for

Answer 14

• increase [PLI]

Question 15

for canine cases: trying to detect decrease functional tissues look for

Answer 15

• decrease [TLI]

Question 16

cobalamin is a key factor in ___ metabolism

Answer 16

• folate

Question 17

• cobalt deficiency (cattle)
• preabsorptive defect
• absorptive defect
  can lead to ___ [cobalamin]

Answer 17

• decrease

Question 18

what breeds have a inherited defect in cubam

Answer 18

• giant schanuzers
• border collies
• australian shepherds
• beagles

Question 19

cobalamin is made up of what (2)

Answer 19

• cobalt and vitamin B12

Question 20

what is needed to convert 5-methyltetrahydrofolate to an unsable form of DNA synthesis

Answer 20

• cobalamin

Question 21

if there is a cobalamin deficiency there is a functional ____ deficiency

Answer 21

• folate

Question 22

• cobalamin
• folate
• TLI
  GI profile for weight loss/diarrhea in EPI patients

Answer 22

• increase -WRI
• decrease
• decrease

Question 23

• cobalamin
• folate
• TLI
  GI profile for weight loss/diarrhea in malabsorption proximal SI

Answer 23

• decrease
• WRI
• WRI

Question 24

• cobalamin
• folate
• TLI
  GI profile for weight loss/diarrhea in distal SI

Answer 24

• WRI
• Decrease
• WRI

Question 25

- cobalamin - folate - TLI GI profile for weight loss/diarrhea in diffuse SI

Answer 25

- Decrease - Decrease - WRI

Question 26

- cobalamin - folate - TLI GI profile for weight loss/diarrhea in bacterial overgrowth

Answer 26

- increase - decrease - WRI

Question 27

increasing fecal alpha1-protease inhibitor concentration suggests a

Answer 27

- protein-losing enteropathy (PLE)

Question 28

alpha 1 - protesase inhibitor concentration is present in ___, ____ and ___ resistant to _____ in feces and molecular weight is similar to ____

Answer 28

- plasma, interstitial fluid and lymph - proteolysis - albumin