P6 - Erythrocytes

Question 1

Anemia in CBC

Answer 1

• decreased Hct
• decreased [Hgb]
• decreased [RBC]

Question 2

anemia classifications

Answer 2

• by marrow responsiveness
• morphologic classification
• pathophysiologic classification

Question 3

regenerative anemia

Answer 3

• presence of reticulocytes

Question 4

nonregenerative anemia

Answer 4

• reticulocytes not present

Question 5

MCV

Answer 5

• mean cell volume

- macrocytic, microcytic, normocytic

Question 6

MCHC

Answer 6

• mean cell hemoglobin concentration

- hyperchromic, hypochromic, nromochromic

Question 7

reticulocytosis expected how many days after onset of anemia

Answer 7

• 3-4 days

Question 8

peak reticulocytosis expected how many days after onset of anemia

Answer 8

• 7-10 days

Question 9

discocytes

Answer 9

• normocytes

Question 10

codocytes

Answer 10

• RBC with appearance of shooting target

Question 11

codocytes usually seen with what type of anemia

Answer 11

• regenerative

Question 12

codocytes in non-regenerative anemia normally indicates

Answer 12

• an iron deficiency

Question 13

rouleau is a sign of

Answer 13

• increased plasma protein usually due to inflammation and/or dehydration

Question 14

saline dilution (dispersion) test

Answer 14

• 1 drop of blood with 9 drops saline

- will disperse Rouleaux

Question 15

agglutination formation

Answer 15

• usually antibodies form bridges between cells

- look like grape like clusters

Question 16

rubricytosis reason

Answer 16

• early or inappropriate release from hemic tissue

Question 17

hypochromic erythrocytes

Answer 17

• increase in central pallor due to decrease Hg content

Question 18

hypochromic erythrocytes due to Fe deficiency trends in MCV, MCHC, and MCH

Answer 18

• decreased MCV, MCHC, and MCH

Question 19

hypochromic erythrocytes due to regenerative anemia trends in MCV, MCHC, and MCH

Answer 19

• increased MCV
• decreased MCHC
• WRI-increased MCH

Question 20

spherocytes

Answer 20

• denser with same volume as discocyte

- sphere shaped

Question 21

Howell-Jolly bodies formation

Answer 21

• nuclear remnant (chromation) left behind after mitosis of nRBC

Question 22

basophilic stippling formation

Answer 22

• ribosomal RNA not degraded

Question 23

Heinz bodies formation

Answer 23

• protrusions of red cells caused by oxidation of Hbg

Question 24

Howell-Jolly bodies significance (2)

Answer 24

• increase erythropoiesis

- decrease splenic function or splenectomy

Question 25

Basophilic stippling significance (2)

Answer 25

- regenerative anemias (cattle) | - canine lead poisoning

Question 26

sinusoidal spleen in what species

Answer 26

- horses | - dogs

Question 27

nonsinusoidal spleen in what species

Answer 27

- cats

Question 28

erythropoietin (EPO) is the hormone that drives what?

Answer 28

- production of bone marrow

Question 29

causes of anemia (3)

Answer 29

- blood loss - hemolysis - decreased production

Question 30

types of anemia by bone marrow responsiveness (2)

Answer 30

- regenerative | - non-regenerative

Question 31

morphologic classifications of anemia (2)

Answer 31

- MCV | - MCHC

Question 32

signs of regeneration in horses

Answer 32

- macrocytosis

Question 33

polychromasia

Answer 33

- increase in young red blood cells in the blood

Question 34

macrocytic, hypochromic usually associated with regenerative or non-regenerative anemia

Answer 34

- regenerative

Question 35

normocytic, normochromic usually associated with regenerative or non-regenerative anemia

Answer 35

- non-regenerative

Question 36

microcytic, hypochromic usually associated with regenerative or non-regenerative anemia

Answer 36

- non-regenerative

Question 37

species in which erythrocytes form rouleaux easily

Answer 37

- equine

Question 38

agglutination significance (3)

Answer 38

- cold antibody causing agglutination - heparin-induced in horses - interferes with cell counting and size methods (decrease [RBC] and increase MCV)