P18 - Secondary Hemostatic Disorders

Question 1

goal of secondary hemostasis

Answer 1

• utilization of coagulation factors to form a fibrin clot

- complex interaction of extrinsic, intrinsic and common pathways

Question 2

intrinsic and common pathways problems result in

Answer 2

• hemophilias

Question 3

extrinsic and common pathways problems result in

Answer 3

• deficiency/antagonists of vit K

Question 4

intrinsic and common pathways clin path abnormalities

Answer 4

• prolonged PTT
• prolonged CT
• prolonged ACT

Question 5

extrinsic and common pathways clin path abnormalities

Answer 5

• prolonged PT

- prolonged PIVKA

Question 6

prolonged PIVKA strongly suggests

Answer 6

• warfarin poisoning

Question 7

cells involved in secondary hemostasis (2)

Answer 7

• fibroblasts (express tissue factor (TF))

- leukocytes, endothelial cells and activated platelets (express phosphatidylserine (PS) surface)

Question 8

major inhibitor of secondary hemostasis (2)

Answer 8

• antithrombin produced in liver

- TF pathway inhibitor produced by endothelial cells

Question 9

disorders of secondary hemostasis (3)

Answer 9

• extrinsic factor VII, TF
• intrinsic factor XII, XI, IX, VIII
• common factor

Question 10

extrinsic factor VII has shortest

Answer 10

• 1/2 life

Question 11

activated partial thromboplastin time (PTT)

Answer 11

• time it takes to form clot

Question 12

activated coagulation time (ACT)

Answer 12

• first evidence of clotting

Question 13

coagulation time (CT)

Answer 13

• first evidence of clot

Question 14

Cause of vitamin K deficiency

Answer 14

• Warfarin

Question 15

One Stage Prothrombin Time (PT)

Answer 15

• time to clot formation