P13 - Leukocytes Part 3

Question 1

diseases and conditions that cause lymphocytosis

Answer 1

• chronic inflammation
• physiologic (shift) - fight or flight
• lymphoproliferative disorders

Question 2

pathogenesis of chronic inflammation causing lymphocytosis

Answer 2

• macrophages and lymphocytes release cytokines -> stimulate production of lymphocytes in lymph nodes -> lymphoid hyperplasia -> increase production and release of lymphocytes to blood

Question 3

pathogenesis of physiologic (shift) causing lymphocytosis

Answer 3

• increase catecholamine -> down regulation of adhesion proteins in vessels -> shift from marginating to circulating pool
• increase blood flow rate -> shift from marginating to circulating pool

Question 4

pathogenesis of lymphoproliferative disorders causing lymphocytosis

Answer 4

• neoplastic transformation of lymphocyte -> clonal proliferation of neoplastic lymphocytes -> increase production and release of neoplastic lymphocytes

Question 5

physiologic shift of lymphocytes most commonly seen in

Answer 5

• cats

Question 6

common causes of monocytosis

Answer 6

• inflammation (acute or chronic)

- steroids (stress)

Question 7

common causes of eosinophilia

Answer 7

• hypersensitivity/allergic disorders
• parasitism
• mast cell degranulation
• idiopathic eosinophil conditions

Question 8

common causes of basophilia

Answer 8

• hypersensitivity/allergic disorders

- parasitism