P14 - Leukocytosis Part 4

Question 1

leukopenia

Answer 1

• decrease [leukocytes]

Question 2

diseases and conditions that cause neutropenia (5)

Answer 2

• inflammation
• peripheral destruction
• granulocytic hypoplasia
• ineffective production
• cyclic hematopoiesis

Question 3

pathogenesis of inflammation causing neutropenia

Answer 3

• acute infection (severe) -> macrophages and lymphocytes release cytokines
• cytokines stimulate migration of neutrophils to inflamed tissue
• cytokines stimulate release of bands from maturation pool

Question 4

pathogenesis of granulocytic hypoplasia causing neutropenia

Answer 4

• damages granulocytic stem cells -> decrease granulocytic precursors -> decrease production of neutrophils
• decrease erythroid precursors and megakaryocytes

Question 5

aplastic anemia

Answer 5

• anemia, neutropenia and thrombocytopenia due to decrease production of cells

Question 6

disease and conditions that cause lymphopenia (4)

Answer 6

• acute inflammation
• steroid
• depletion
• lymphoid hypoplasia or aplasia

Question 7

pathogenesis of acute inflammatory causing lymphopenia

Answer 7

• macrophages and lymphocytes release cytokines -> promote homing of lymphocytes to lymph nodes
• cytokines promote lymph migration to inflamed tissues

Question 8

pathogenesis of steroid use causing lymphopenia

Answer 8

• increase glucocorticoids -> shift of lymphocytes from circulation pool to marrow
• lymphotoxic effects might occur

Question 9

pathogenesis of depletion causing lymphopenia

Answer 9

• damage to lymphatic vessel -> loss of lymph into pleural or peritoneal cavity -> depletes body of circulating lymphocytes

Question 10

acute inflammatory disorder causing lymphopenia expect to also see either

Answer 10

• neutrophilia with left shift

- inflammatory neutropenia

Question 11

leukogram pattern:

• decrease total WBC
• decrease segs
• WRI non segs
• decrease lymphocytes
• WRI monocytes
• decrease to WRI eosinophils

Answer 11

• acute inflammatory (endotoxemia)