P17 - Primary Hemostatic Disorders

Question 1

primary hemostasis involves

Answer 1

• vasoconstriction

- platelet adhesion

Question 2

secondary hemostasis involves

Answer 2

• coagulation cascade

Question 3

tertiary hemostasis involves

Answer 3

• fibrinolysis

Question 4

thrombocytopenia

Answer 4

• low platelet count (quantity)

Question 5

pseudothrombocytopenia

Answer 5

• false thrombocytopenia
• cats (large platelets)
• horses when blood in EDTA tube

Question 6

thrombocytosis

Answer 6

• increased platelet count

Question 7

thrombocytopathy

Answer 7

• loss or impaired platelet function

- think vWD

Question 8

BMBT

Answer 8

buccal mucosal bleeding time

Question 9

clinical pathology abnormalities in vWD (4)

Answer 9

• Thrombocrit is less than 1%
• BMBT is prolonged
• CRT is abnormal (prolonged)
• Clot lysis is abnormal

Question 10

hemostasis is an interaction between (4)

Answer 10

• blood vessels
• platelets
• coagulation factors
• fibrinolysis

Question 11

evaluation of coagulopathies (5)

Answer 11

• onset of bleeding
• age
• history
• environmental evidence
• coagulation profile

Question 12

sample collection that test PTT and PT (secondary hemostasis)

Answer 12

• sodium citrate

Question 13

sample collection that test platelet counts, thrombocrit, MPV (primary hemostasis)

Answer 13

• EDTA

Question 14

sample collection that test platelet CT, ACT, CRT

Answer 14

• plain tubes

Question 15

goal of primary hemostasis (2)

Answer 15

• formation of platelet plug

- vasoconstriction

Question 16

proteins of primary hemostasis (3)

Answer 16

• vWF
• collagen
• fibrinogen binds platelets

Question 17

major inhibitor of primary hemostasis (2)

Answer 17

• prostacyclin (prostaglandin P-12)

- Nitric oxide produced by endothelial cells

Question 18

quality of platelets described as

Answer 18

• thrombocytopathy

Question 19

quantity of platelets described as

Answer 19

• thrombocytopenia

Question 20

petechiae

Answer 20

• pinpoint hemorrhages

- indicative of platelet or blood vessel problem

Question 21

test for platelets (5)

Answer 21

• thrombocrit or plateletocrit
• platelet counts
• platelet distribution width
• measurement of anti-platelet antibodies
• flow cytometry

Question 22

factors that could cause prolonged bleeding time (2)

Answer 22

• vascular or platelet (quantity and quality)

- von Willebrand’s disease

Question 23

clot retraction time (CRT) technique

Answer 23

• red top tube

Question 24

platelet aggregation test measures

Answer 24

• ability of platelets to clot (speed and degree)

Question 25

clinical presentation of vWD

Answer 25

- bleeding in gums, epistaxis, hematuria, melena | - small puppies bleed excessively

Question 26

clinical pathology abnormalities of vWD (7)

Answer 26

- coagulation test are WRI (PTT & PT) - thrombocrit is less than 1% - platelet count is WRI - BMBT is prolonged - CRT is abnormal - clot lysis is abnormal - low vWF

Question 27

reasons for thrombocytopenia (4)

Answer 27

- inadequate production - increased utilization - increased destruction - clinical pathology abnormalities

Question 28

pseudothrombocytopenia due to (3)

Answer 28

- platelet clumping - bad sample collection - band sample handling

Question 29

naturally susceptible species of pseudothrombocytopenia

Answer 29

- cats and pigs | - horses blood in EDTA

Question 30

thrombocytosis occurs secondary to (4)

Answer 30

- leukoerythroblastic response - neoplasia - inflammation - hemolysis