Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmacology > METABOLIC PROFILE DRUGS - Hypothalamic & Pituitary Hormones, Thyroid & Antithyroid Drugs > Flashcards

METABOLIC PROFILE DRUGS - Hypothalamic & Pituitary Hormones, Thyroid & Antithyroid Drugs Flashcards

1
Q

Hormones are

A

Products of endocrine gland secretion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

An endocrine drug which is an amino acid derivative

A

Thyroxine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

An endocrine drug which is a peptide derivative

A

Oxitocin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

An endocrine drug which is a steroidal derivative

A

Hydrocortisone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Hormone analogues are

A

Synthetic compounds, which resemble the naturally occurring hormones

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

True or False about mechanism of action of hormones. Hormones interact with the specific receptors in the wall of the cells

A

FALSE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

True or False about mechanism of action of hormones. Cyclic AMP acts as a second messenger system

A

TRUE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

True or False about mechanism of action of hormones. They stimulate adenylcyclase enzyme

A

TRUE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

True or False about mechanism of action of hormones. Many hormones owe their effect to primary actions on subcellular membrane.

A

TRUE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Hypothalamic and pituitary hormones (and their synthetic analogs) have pharmacologic applications in three areas

A
  • As replacement therapy for hormone deficiency states
  • As drug therapy for a variety of disorders using pharmacologic doses to elicit a hormonal effect that is not present at physiologic a blood levels
  • As a diagnostic tool for performing stimulation tests to diagnose hypo- or hyperfunctional endocrine states
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Hypothalamic and pituitary hormones (and their synthetic analogs) have pharmacologic applications in three areas, excet

A

As food supplements

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Which hormones is produced by the hypothalamic gland?

A

Growth hormone-releasing hormone (GHRH)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Which hormones is produced by the anterior lobe of the pituitary?

A

Growth hormone (somatotropin, GH)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

The posterior pitutary does NOT secret

A

Growth hormone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

The posterior pitutary secret

A
  • Vasopressin

- Oxytocin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Which organs is a target for prolactin?

A

Mammary gland

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Which organ hormones is a target for growth hormone (somatotropine, GH)?

A

Insulin-like growth factors (IGF, somatomedins)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

True or False about growth hormone. It may stimulate the synthesis or release of somatomedins

A

TRUE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

True or False about growth hormone.Low levels of insulin-like growth factor (IGF)-1 are associated with dwarfism

A

TRUE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

True or False about growth hormone. Hypersecretion can result in acromegaly

A

FALSE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

True or False about growth hormone. It is contraindicated in subjects with closed epiphyses

A

TRUE

22
Q

adrenocorticotropic hormone (ACTH) include

A
  • Endogenous ACTH is also called corticotropin
  • ACTH stimulates the synthesis of corticosteroids
  • ACTH is most useful clinically as a diagnostic tool in adrenal insufficiency
23
Q

adrenocorticotropic hormone (ACTH) do not include

A

The oral route is the preferred rout of administration

24
Q

True or False. The hypothalamic control exists for the thyroid gland.

A

TRUE

25
Q

Indications of bromocriptine are

A
  • Prolactin-secreting adenomas
  • Amenorrhea-Galactorrhea
  • Acromegaly
26
Q

Indications of bromocriptine are not

A

Prolactin deficiency

27
Q

Currently used dopamine agonists decreasing pituitary prolactin secretion are following

A
  • Bromocriptine
  • Cabergoline
  • Pergolide
28
Q

Indications of oxitocin are

A
  • Labor and augment dysfunctional labor for conditions requiring early vaginal delivery
  • Incompleted abortion
  • For control of pospartum uterine hemorrhage
29
Q

Indications of vasopressin are

A

Pituitary diabetes insipidus

30
Q

Vasopressin possesses the following

A

Antidiuretic property

31
Q

Oxytocin produces the following effects

A
  • It causes contraction of the uterus
  • It assists the progress of spermatozoa into the uterine cavity
  • It brings about milk ejection from the lactating mammary gland
32
Q

Vasopressin causes a pressor effect by

A

A direct action on smooth muscles of the blood vessels

33
Q

True or False. Hypothyroidism is a syndrome resulting from deficiency of thyroid hormones and is manifested largely by a reversible slowing down of all body functions

A

True

34
Q

Which hormones is produced by the thyroid gland?

A

Thyroxine

35
Q

Which hormones is produced by the thyroid gland?

A

Triiodothyronine

36
Q

Thyroid stimulating hormone regulates the following

A
  • Iodine uptake
  • Biosynthesis of iodothyroglobulin
  • Release of thyroid hormone into the plasma
37
Q

True or False about Thyroid hormones. Decline of the basal metabolic rate in the body

A

FALSE

38
Q

True or False about Thyroid hormones. Increase in the rate and force of contraction of the heart

A

TRUE

39
Q

True or False about Thyroid hormones. Increase in the blood cholestrol level

A

TRUE

40
Q

True or False about Thyroid hormones. Increase in the heat production

A

TRUE

41
Q

Synthesis and release of thyroid hormones are controlled by

A
  • Anterior pituitary alone
  • Hypothalamus alone
  • Blood levels of thyroid hormones alone
42
Q

Thyrotrophin stimulates

A

Release of thyroxine and triidothyronine

43
Q

The rate of secretion of thyrotropin is controlled by

A

The concentration of thyroid hormones in blood

44
Q

Indications of thyroid hormones are

A
  • Cretinism
  • Myxoedema
  • Hashimoto’s disease
45
Q

The common side effect of thyroid hormones is

A

Exopthalmos

46
Q

Currently used antithyroid drugs include the following

A
  • Propylthiouracil (PTU)
  • Diatrizoate sodium (Hypaque)
  • Methimazole (Tapazole)
47
Q

In an area where goitre is endemic, which of the following drugs is used?

A

Iodide 1 part in 100000

48
Q

Iodide preparations can be used in following situations

A
  • In thyroid disorders
  • In granulomatous lesions e.g. Syphilis
  • As an antiseptic
49
Q

Iodide preparations can not be used in following situations

A

In iodism

50
Q

Daily administration of large doses (several milligrammes) of iodides to a thyrotoxic patient causes

A

Thyroid gland growing firm and less vascular

51
Q

Radioiodines (I131 and I132) is suitable for

A

Elderly patients (over 45 years)

52
Q

Radioiodines in the body emit

A

Mainly β radiations

Pharmacology (41 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions