AGENTS, CONTROLLING THE FUNCTIONS OF THE CENTRAL NERVOUS SYSTEM - Anxiolytic agents Flashcards
Anxiolytics are used to treat
Neurosis
Anxiolytic agents should
Reduce anxiety and exert a calming effect
Anxiolytics are also useful for
- Treatment of epilepsy and seizures
- Insomnia
- Muscle relaxation in specific neuromuscular disorders
Indicate the agents of choice in the treatment of most anxiety states
Benzodiazepines
The choice of benzodiazepines for anxiety is based on
- A relatively high therapeutic index
- Availability of flumazenil for treatment of overdose
- A low risk of physiologic dependence
Which anxiolitics is a benzodiazepine derivative
Clordiazepoxide
Indicate the benzodiazepine, which has the shortest elimination half-life
Triazolam
Which benzodiazepines has the shortest duration of action?
Triazolam
Which benzodiazepines is less likely to cause cumulative and residual effects with multiple doses?
Lorazepam
Anxiolytic dosage reduction is recommended
- In patients taking cimetidine
- In patients with hepatic dysfunction
- In elderly patients
Which benzodiazepines is preferred for elderly patients?
Triazolam
Which anxiolytics is preferred in patient with limited hepatic function?
Buspirone
Indicate the mechanism of hypnotic benzodiazepine action
Increasing the frequency of Cl- channel opening events
Which anxiolytics is a partial agonist of brain 5-HT1A receptors?
Buspirone
Indicate the competitive antagonist of BZ receptors
Flumazenil