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Pharmacology > CHEMOTHERAPEUTIC DRUGS - ANTIVIRAL AGENTS. AGENTS FOR CHEMOTHERAPY OF CANCER > Flashcards

CHEMOTHERAPEUTIC DRUGS - ANTIVIRAL AGENTS. AGENTS FOR CHEMOTHERAPY OF CANCER Flashcards

1
Q

The following antiviral drugs are the analogs of nucleosides

A

Saquinavir

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2
Q

The drug, a derivative of adamantane

A

Rimantadine

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3
Q

The drug, a derivative of pyrophosphate

A

Foscarnet

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4
Q

The drug, inhibiting viral DNA synthesis

A

Acyclovir

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5
Q

The drug, inhibiting uncoating of the viral RNA

A

Rimantadine

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6
Q

The drug, inhibiting viral reverse transcriptase

A

Zidovudine

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7
Q

The drug, inhibiting viral proteases

A

Saquinavir

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8
Q

The drug of choice for herpes and cytomegalovirus infection treatment

A

Acyclovir

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9
Q

The drug which belongs to nonnucleoside reverse transcriptase inhibitors

A

Nevirapine

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10
Q

The following antiviral drugs are antiretroviral agents

A
  • Zidovudine
  • Zalcitabine
  • Didanozine
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11
Q

The drug used for influenza A prevention

A

Rimantadine

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12
Q

The drug used for HIV infection treatment, a derivative of nucleosides

A

Zidovudine

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13
Q

The antiviral drug which belongs to endogenous proteins

A

Interferon alfa

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14
Q

The drug which belongs to nucleoside reverse transcriptase inhibitors

A

Didanosine

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15
Q

The following antiviral drugs are anti-influenza agents

A
  • Amantadine
  • Interferons
  • Rimantadine
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16
Q

The unwanted effects of zidovudine

A

Anemia, neutropenia, nausea, insomnia

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17
Q

The unwanted effects of intravenous acyclovir infusion

A

Renal insufficiency, tremors, delerium

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18
Q

The drug that can induce peripheral neuropathy and oral ulceration

A

Zalcitabine

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19
Q

The unwanted effects of didanozine

A

Peripheral neuropathy, pancreatitis, diarrhea, hyperuricemia

20
Q

The unwanted effects of indinavir

A

Nephrolithiasis, nausea, hepatotoxicity

21
Q

The drug that can induce nausea, diarrhea, abdominal pain and rhinitis

A

Saquinavir

22
Q

The following effects are disadvantages of anticancer drugs

A
  • Low selectivity to cancer cells
  • Depression of bone marrow
  • Depression of immune system
23
Q

Rational combination of anticancer drugs is used to

A

Provide synergism resulting from the use of anticancer drugs with different mechanisms combination

24
Q

The anticancer alkylating drug, a derivative of chloroethylamine

A

Cyclophosphamide

25
Q

The anticancer alkylating drug, a derivative of ethylenimine

A

Thiotepa

26
Q

The group of hormonal drugs used for cancer treatment

A

Glucocorticoids and gonadal hormones

27
Q

The anticancer alkylating drug, a derivative of alkylsulfonate

A

Busulfan

28
Q

The anticancer drug of plant origin

A

Vincristine

29
Q

Action mechanism of alkylating agents is

A

Producing carbonium ions altering DNA structure

30
Q

The anticancer drug, a pyrimidine antagonist

A

Fluorouracil

31
Q

Methotrexate is

A

A folic acid antagonist

32
Q

The antibiotic for cancer chemotherapy

A

Doxorubicin

33
Q

Fluorouracil belongs to

A

Antimetabolites

34
Q

The action mechanism of anticancer drugs belonging to plant alkaloids

A

Mitotic arrest at a metaphase

35
Q

General contraindications for anticancer drugs are

A
  • Depression of bone marrow
  • Acute infections
  • Severe hepatic and/or renal insufficiency
36
Q

Action mechanism of methotrexate is

A

Inhibition of dihydrofolate reductase

37
Q

The anticancer drug belonging to inorganic metal complexes

A

Cisplatin

38
Q

The indication for estrogens in oncological practice

A

Cancer of prostate

39
Q

Enzyme drug used for acute leukemia treatment

A

Dihydrofolate reductase

40
Q

The following drugs are derivatives of nitrosoureas

A
  • Carmustine
  • Lomustine
  • Semustine
41
Q

The group of drugs used as subsidiary medicines in cancer treatment

A
  • Cytoprotectors
  • Bone marrow growth factors
  • Antimetastatic agents
42
Q

Estrogen inhibitor

A

Tamoxifen

43
Q

Antiandrogen drug

A

Flutamide

44
Q

The drug belonging to aromatase inhibitors

A

Anastrozole

45
Q

The drug belonging to gonadotropin-releasing hormone agonists

A

Leuprolide

Pharmacology (41 decks)

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