CHEMOTHERAPEUTIC DRUGS - ANTIVIRAL AGENTS. AGENTS FOR CHEMOTHERAPY OF CANCER Flashcards

1
Q

The following antiviral drugs are the analogs of nucleosides

A

Saquinavir

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

The drug, a derivative of adamantane

A

Rimantadine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

The drug, a derivative of pyrophosphate

A

Foscarnet

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

The drug, inhibiting viral DNA synthesis

A

Acyclovir

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

The drug, inhibiting uncoating of the viral RNA

A

Rimantadine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

The drug, inhibiting viral reverse transcriptase

A

Zidovudine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

The drug, inhibiting viral proteases

A

Saquinavir

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

The drug of choice for herpes and cytomegalovirus infection treatment

A

Acyclovir

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

The drug which belongs to nonnucleoside reverse transcriptase inhibitors

A

Nevirapine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

The following antiviral drugs are antiretroviral agents

A
  • Zidovudine
  • Zalcitabine
  • Didanozine
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

The drug used for influenza A prevention

A

Rimantadine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

The drug used for HIV infection treatment, a derivative of nucleosides

A

Zidovudine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

The antiviral drug which belongs to endogenous proteins

A

Interferon alfa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

The drug which belongs to nucleoside reverse transcriptase inhibitors

A

Didanosine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

The following antiviral drugs are anti-influenza agents

A
  • Amantadine
  • Interferons
  • Rimantadine
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

The unwanted effects of zidovudine

A

Anemia, neutropenia, nausea, insomnia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

The unwanted effects of intravenous acyclovir infusion

A

Renal insufficiency, tremors, delerium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

The drug that can induce peripheral neuropathy and oral ulceration

A

Zalcitabine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

The unwanted effects of didanozine

A

Peripheral neuropathy, pancreatitis, diarrhea, hyperuricemia

20
Q

The unwanted effects of indinavir

A

Nephrolithiasis, nausea, hepatotoxicity

21
Q

The drug that can induce nausea, diarrhea, abdominal pain and rhinitis

A

Saquinavir

22
Q

The following effects are disadvantages of anticancer drugs

A
  • Low selectivity to cancer cells
  • Depression of bone marrow
  • Depression of immune system
23
Q

Rational combination of anticancer drugs is used to

A

Provide synergism resulting from the use of anticancer drugs with different mechanisms combination

24
Q

The anticancer alkylating drug, a derivative of chloroethylamine

A

Cyclophosphamide

25
The anticancer alkylating drug, a derivative of ethylenimine
Thiotepa
26
The group of hormonal drugs used for cancer treatment
Glucocorticoids and gonadal hormones
27
The anticancer alkylating drug, a derivative of alkylsulfonate
Busulfan
28
The anticancer drug of plant origin
Vincristine
29
Action mechanism of alkylating agents is
Producing carbonium ions altering DNA structure
30
The anticancer drug, a pyrimidine antagonist
Fluorouracil
31
Methotrexate is
A folic acid antagonist
32
The antibiotic for cancer chemotherapy
Doxorubicin
33
Fluorouracil belongs to
Antimetabolites
34
The action mechanism of anticancer drugs belonging to plant alkaloids
Mitotic arrest at a metaphase
35
General contraindications for anticancer drugs are
- Depression of bone marrow - Acute infections - Severe hepatic and/or renal insufficiency
36
Action mechanism of methotrexate is
Inhibition of dihydrofolate reductase
37
The anticancer drug belonging to inorganic metal complexes
Cisplatin
38
The indication for estrogens in oncological practice
Cancer of prostate
39
Enzyme drug used for acute leukemia treatment
Dihydrofolate reductase
40
The following drugs are derivatives of nitrosoureas
- Carmustine - Lomustine - Semustine
41
The group of drugs used as subsidiary medicines in cancer treatment
- Cytoprotectors - Bone marrow growth factors - Antimetastatic agents
42
Estrogen inhibitor
Tamoxifen
43
Antiandrogen drug
Flutamide
44
The drug belonging to aromatase inhibitors
Anastrozole
45
The drug belonging to gonadotropin-releasing hormone agonists
Leuprolide