CHEMOTHERAPEUTIC DRUGS - SYNTHETIC ANTIBACTERIAL DRUGS

Question 1

Sulfonamides are effective against

Answer 1

• Bacteria and Chlamidia
• Actinomyces
• Protozoa

Question 2

Mechanism of sulfonamides’ antibacterial effect is

Answer 2

Inhibition of dihydropteroate synthase

Question 3

Combination of sulfonamides with trimethoprim

Answer 3

Increases the antimicrobial activity

Question 4

Sulfonamide potency is decreased in case of co-administration with

Answer 4

Local anesthetics – derivatives of paraaminobenzoic acid

Question 5

The following measures are necessary for prevention of sulfonamide precipitation and crystalluria

Answer 5

Taking of drinks with alkaline pH

Question 6

Resorptive sulfonamides have the following unwanted effects on blood system

Answer 6

• Hemolytic anemia
• Thrombocytopenia
• Granulocytopenia

Question 7

Mechanism of Trimethoprim’ action is

Answer 7

Inhibition of dihydropteroate reductase

Question 8

Sulfonamides have the following unwanted effects

Answer 8

• Hematopoietic disturbances
• Crystalluria
• Nausea, vomiting and diarrhea

Question 9

The drug, which is effective against mycobacteria only

Answer 9

Isoniazid

Question 10

The antimycobacterial drug belonging to first-line agents

Answer 10

Isoniazid

Question 11

The antimycobacterial drug, belonging to second-line agents

Answer 11

PAS

Question 12

The antimycobacterial drug, belonging to antibiotics

Answer 12

Rifampin

Question 13

Mechanism of Izoniazid action is

Answer 13

Inhibition of mycolic acids synthesis

Question 14

Mechanism of Rifampin action is

Answer 14

Inhibition of DNA dependent RNA polymerase

Question 15

Mechanism of Cycloserine action is

Answer 15

Inhibition of cell wall synthesis

Question 16

Mechanism of Streptomycin action is

Answer 16

Inhibition of protein synthesis

Question 17

Rifampin has the following unwanted effect

Answer 17

Flu-like syndrome, tubular necrosis

Question 18

Isoniazid has following unwanted effect

Answer 18

Hepatotoxicity, peripheral neuropathy

Question 19

Ethambutol has the following unwanted effect

Answer 19

Retrobulbar neuritis with red-green color blindness

Question 20

Streptomycin has the following unwanted effect

Answer 20

Ototoxicity, nephrotoxicity

Question 21

Mechanism of aminosalicylic acid action is

Answer 21

Inhibition of folate synthesis

Question 22

The following agents are the first-line antimycobacterial drugs

Answer 22

• Rifampin
• Isoniazid
• Streptomycin

Question 23

The following antimycobacterial drugs have a bactericidal effect

Answer 23

• Streptomycin
• Rifampin
• Isoniazid

Question 24

Combined chemotherapy of tuberculosis is used to

Answer 24

Decrease mycobacterium drug-resistance

Question 25

Antibacterial drug – a nitrofurane derivative

Answer 25

Nitrofurantoin

Question 26

Antibacterial drug – a nitroimidazole derivative

Answer 26

Metronidazole

Question 27

Antibacterial drug – a quinolone derivative

Answer 27

Nalidixic acid

Question 28

Antibacterial drug – a fluoroquinolone derivative

Answer 28

Ciprofloxacin

Question 29

The indications for nitrofuranes

Answer 29

Infections of urinary and gastro-intestinal tracts

Question 30

The unwanted effects of nitrofuranes

Answer 30

- Nausea, vomiting - Allergic reactions - Hemolytic anemia

Question 31

The indications for Metronidazole

Answer 31

Intra-abdominal infections, vaginitis, enterocolitis

Question 32

The unwanted effects of Metronidazole

Answer 32

Nausea, vomiting, diarrhea, stomatitis

Question 33

The mechanism of fluoroquinolones’ action is

Answer 33

Inhibition of DNA gyrase

Question 34

Fluoroquinolones are active against

Answer 34

Variety of Gram-negative and positive microorganisms, including Mycoplasmas and Chlamidiae

Question 35

The unwanted effects of fluoroquinolones

Answer 35

Headache, dizziness, insomnia

Question 36

The indications for fluoroquinolones

Answer 36

Infections of the urinary and respiratory tract, bacterial diarrhea

Question 37

The drug of choice for syphilis treatment is

Answer 37

Penicillin