CHEMOTHERAPEUTIC DRUGS - SYNTHETIC ANTIBACTERIAL DRUGS Flashcards
Sulfonamides are effective against
- Bacteria and Chlamidia
- Actinomyces
- Protozoa
Mechanism of sulfonamides’ antibacterial effect is
Inhibition of dihydropteroate synthase
Combination of sulfonamides with trimethoprim
Increases the antimicrobial activity
Sulfonamide potency is decreased in case of co-administration with
Local anesthetics – derivatives of paraaminobenzoic acid
The following measures are necessary for prevention of sulfonamide precipitation and crystalluria
Taking of drinks with alkaline pH
Resorptive sulfonamides have the following unwanted effects on blood system
- Hemolytic anemia
- Thrombocytopenia
- Granulocytopenia
Mechanism of Trimethoprim’ action is
Inhibition of dihydropteroate reductase
Sulfonamides have the following unwanted effects
- Hematopoietic disturbances
- Crystalluria
- Nausea, vomiting and diarrhea
The drug, which is effective against mycobacteria only
Isoniazid
The antimycobacterial drug belonging to first-line agents
Isoniazid
The antimycobacterial drug, belonging to second-line agents
PAS
The antimycobacterial drug, belonging to antibiotics
Rifampin
Mechanism of Izoniazid action is
Inhibition of mycolic acids synthesis
Mechanism of Rifampin action is
Inhibition of DNA dependent RNA polymerase
Mechanism of Cycloserine action is
Inhibition of cell wall synthesis