Malaria in Pregnancy - MCH Flashcards

1
Q

What is the causative agent of malaria?

A

Malaria is caused by Plasmodium parasites.

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2
Q

Which species of Plasmodium is the most deadly?

A

Plasmodium falciparum.

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3
Q

How is malaria transmitted?

A

Through the bites of infected female Anopheles mosquitoes, primarily from dusk to dawn.

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4
Q

Which populations are most at risk for severe malaria infections?

A

Young children, non-immune pregnant women, semi-immune HIV-infected pregnant women, and travellers from non-endemic areas.

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5
Q

How many annual malaria deaths occur globally, and what percentage is in Africa?

A

About a million deaths annually, with 91% in Africa.

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6
Q

What are the four species of Plasmodium that infect humans?

A

Plasmodium falciparum, P. vivax, P. malariae, and P. ovale.

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7
Q

What factors affect the intensity of malaria transmission?

A

The parasite, the vector, the human host, and the environment.

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8
Q

What is the role of Anopheles mosquitoes in malaria transmission?

A

They act as definitive hosts and vectors for Plasmodium parasites.

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9
Q

What are the incubation period and common symptoms of acute malaria?

A

10–15 days; symptoms include fever, headache, muscle aches, nausea, and vomiting.

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10
Q

How is malaria diagnosed?

A

By thick and thin blood films, and additional investigations for severe cases.

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11
Q

Name two differential diagnoses for malaria in pregnancy.

A

Chorioamnionitis and urinary tract infections.

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12
Q

Why are primigravidae more affected by malaria during pregnancy?

A

Pregnancy decreases acquired immunity, especially in the 1st and 2nd trimesters.

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13
Q

What maternal complications can malaria cause during pregnancy?

A

Acute haemolysis, cerebral malaria, renal failure, threatened abortion, and premature labour.

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14
Q

How does malaria affect the placenta and the foetus?

A

The placental barrier limits parasite passage, and maternal antibodies provide passive immunity.

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15
Q

List two complications of malaria in the foetus.

A

Prematurity and intrauterine growth restriction.

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16
Q

What is the first-line antimalarial therapy for uncomplicated malaria in the first trimester?

A

Quinine with or without clindamycin.

17
Q

What treatments are recommended for complicated malaria during pregnancy?

A

Parenteral quinine, artesunate, or artemether followed by oral therapy.

18
Q

Why is artemisinin preferred over quinine for treating malaria?

A

Artemisinin reduces the risk of miscarriage compared to quinine.

19
Q

What are the three components of malaria prevention in pregnancy?

A

IPTp-SP, LLINs, and effective case management.

20
Q

What is the recommended schedule for intermittent preventive treatment of malaria in pregnancy (IPTp-SP)?

A

IPTp-SP is administered starting in the second trimester at each ANC visit, one month apart.

21
Q

Why should IPTp-SP not be given in the first trimester of pregnancy?

A

SP can harm foetal development during the first trimester.

22
Q

What are the limitations of intermittent screening and treatment in pregnancy (ISTp)?

A

ISTp is less effective and more expensive than IPTp-SP.

23
Q

Why is folic acid supplementation limited to 0.4 mg daily during IPTp-SP?

A

Higher doses counteract the antimalarial efficacy of SP.

24
Q

How do long-lasting insecticidal nets (LLINs) benefit pregnant women?

A

LLINs reduce malaria cases and improve birth outcomes.

25
Q

What additional measures are recommended for pregnant women travelling to malaria-endemic areas?

A

Use preventive measures like chemoprophylaxis and avoid travel to endemic regions.

26
Q

What is the vision of the Global Malaria Action Plan (GMAP)?

A

To achieve a malaria-free world.

27
Q

What is the target of the global technical strategy for malaria 2016–2030?

A

To reduce global malaria incidence and mortality by 90% by 2030.

28
Q

When is World Malaria Day celebrated, and what was the 2017 theme?

A

April 25; “Let’s end malaria for good.”

29
Q

Which three African countries were selected for the malaria vaccine rollout?

A

Ghana, Kenya, and Malawi.

30
Q

What are the consequences of inadequate malaria control during pregnancy?

A

Increased maternal and foetal mortality, low birth weight, and intergenerational poverty.