Lecture 43 - Small Intestine Flashcards

1
Q

Describe the small intestines

A

large surface area of villous mucosa

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2
Q

where does digestion occur in the small intestines

A
  1. intra-luminal (pancreatic enzymes & bile acids)
  2. surface (brush border enzymes)
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3
Q

what is the job of amylase

A

break down carbs

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4
Q

what is the job of lipase

A

break down fats

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5
Q

what is the job of protease

A

break down protein

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6
Q

T/F: to fully digest and absorb nutrients, luminal digestion, brush border digestion, and nutrient transporters are needed

A

TRUE

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7
Q

what are the mucosal folds

A

inner surface of small intestines that form circular folds to increase surface area and regulate flow

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8
Q

what are the villi

A

tiny projections that stick into the lumen covered with cells for absorption

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9
Q

what are the microvilli

A

tiny hairlike structures on villi to increase the surface area of each cell

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10
Q

what cells line the villi

A
  1. Columnar absorptive cells
  2. mucus-secreting goblet cells
  3. Intraepithelial lymphocytes
  4. enterendocrine cells
  5. tuft cells
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11
Q

what cells line the crypt

A
  1. Undifferentiated stem cells that secrete Cl-/water
  2. Paneth cells that secrete anti-microbial peptides and help maintain stem cells
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12
Q

anoikis

A

programmed cell death that occurs after loss of adhesion/contact with cell membrane

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13
Q

what transporters are present in the villus

A
  1. Na-K pump (sodium in)
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14
Q

what transporters are present in the crypt

A
  1. Na-K pump (sodium out)
  2. Na/K/Cl channel (sodium in)
  3. cystic fibrosis transmembrane conductance regulator (Cl- secretion)
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15
Q

describe a defective CFTR

A

accumulation of Cl- in epithelial cells and lack of hydration of extracellular mucus secretions

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16
Q

describe an activated CFTR

A

secretion&raquo_space;> absoprtion
Overactivity releases too many Cl- ions and increases water flow in guts

17
Q

what is D+

A
  1. increase in frequency or volume
  2. occurs w mismatch between secretion and absorption
18
Q

what are the 4 categories of D+

A
  1. osmotic
  2. secretory
  3. malabsorptive
  4. other
19
Q

describe osmotic D+

A

occurs when there are non-absorbable susbtances in the gut that draw water

20
Q

describe malabsorptive D+

A

loss of epithelial cells and inefficient fluid and electrolyte absorption

21
Q

describe secretory D+

A

intestinal cells release more fluid/electrolytes into the lumen

22
Q

what do injuries in the villous epithelium cause

A

severe maldigestion and malabsorption

23
Q

T/F: recovery in villous damage is not possible

A

FALSE - crypt spars stem cells

24
Q

what do injuries in the crypt epithelium cause

A

prevents ability to regenerate raoud turnover rate

25
Q

what are the two types of motility patterns

A
  1. interdigestive (fasting; housekeeping)
  2. Digestive (after meal)
26
Q

what are the 3 functions of intesting motility

A
  1. propulsion
  2. mixing
  3. reservoir
27
Q

describe interdigestive motility

A
  • strong peristaltic contractions
  • “housekeeper” (clean GI)
  • controlled by enteric system
28
Q

what are the 3 phases of interdigestive motility

A

phase I - no contractions
Phase II - intermittent
Phase III - continuous

29
Q

the migrating myoelectirc complex is driven by

30
Q

describe digestive motility

A
  • helps promote digestion and absorption of meal
  • short, peristaltic bursts
  • activation of vagus nerve and hormones
31
Q

what types of contractions are present in digestive motility

A
  1. tonic - sustained, characteristic of sphincters
  2. peristalsis - aboral wave of contraction
  3. segmental - stationary rings of contraction that delay transit
32
Q

in carnivores/omnivores, disgestive motility is stimulated by _____ and is ____

A

vagus nerve; slower

33
Q

T/F: in ruminants, there is no digestive motility pattern