Lec 8/9-3 - Somatosensory System & Pain Flashcards

1
Q

hair receptors are considered to e this type of receptor

A

mechanoreceptor

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2
Q

hair being bent causes mechanoreceptors to change blank and let sodium in and generate blank via voltage gated channels

A

conformation, an action potential

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3
Q

for fine tactile sensation from touch and light pressure

A

meissner corpuscles

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4
Q

meissners corpuscle has blank adaptation

A

rapid

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5
Q

for touch but adapt slowly

A

merkel endings

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6
Q

meissners are located here

A

epithelium

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7
Q

merkels are located here

A

basal epidermis

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8
Q

these are sensitive to vibration

A

pacinian

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9
Q

pacinian adapt blank

A

fast

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10
Q

pacinian are located here

A

ct and subcutaneous throughout entire body

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11
Q

pacinian corpuscles are best for the first signs of blank

A

neuropathy

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12
Q

most common receptor in the mouth

A

ruffini

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13
Q

ruffini is located here

A

subcutaneous and ct

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14
Q

ruffini adapts blank

A

slow

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15
Q

c tactile afferents are myelinated/unmyelinated and involved in blank

A

unmyelinated, pleasure/stroking

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16
Q

location where a change in the stimulus leads to a change in the firing of a cell

A

receptive fields

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17
Q

receptive field size of fingers

A

tiny

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18
Q

some receptive fields are small due to blank

A

inhibitory circuits

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19
Q

more convergence leads to a blank receptive field

A

larger

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20
Q

blank organization tells us where things are and where they are not

A

center surround

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21
Q

most somatosensory information is from this neuron in the column

A

4

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22
Q

blank can modify activity of cortical somatosensory neurons

A

attention

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23
Q

response of tactile sensation is filtered by blank

A

thalamus

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24
Q

periodontal ligaments contain these

A

free nerve endings, ruffini mechanoreceptors

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25
Q

teeth contain blank

A

pain fibers

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26
Q

how many types of dental sensory fibers

A

6

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27
Q

these provide information about tooth loading and direction the teeth are being pushed

A

periodontal ruffini endings

28
Q

periodontal ruffini endings die when blank

A

tooth is pulled and implant is placed

29
Q

detection and localization of a stimulated pain receptor

A

nociceptor

30
Q

this involves the emotional and arousal aspects of such stimulation

A

pain

31
Q

pain and temp are always translated along blank pathways

A

the same

32
Q

thermoreceptors can transmit information of blank or blank temp ranges

A

non noxious, noxious

33
Q

menthol activates these thermoreceptors

A

cold

34
Q

capsaicin in peppers activate these thermoreceptors

A

capsaicin

35
Q

capsaicin works by depleting this transmitter

A

substance p

36
Q

ibuprofen is blank selective compared to aspirin

A

more

37
Q

both aspirin and ibuprofen block blank

A

cox 2

38
Q

aspirin is a blank which selectively blocks pain and doesnt affect other senses

A

analgesic

39
Q

anesthetics block blank so other senses are also affected

A

nonselectively

40
Q

this activates mast cells, macrophages, and neutrophils

A

substance p

41
Q

cgrp and subtance p cause blank which causes edema and more pain

A

vasodilation/plasma leakage

42
Q

increased sensitivity to pain

A

hyperalgesia

43
Q

pain due to a simulus that does not normally provoke pain

A

allodynia

44
Q

painful inflammatory infection of the pulp

A

pulpitis

45
Q

immune cells are the major source of the peripheral blank

A

opioid

46
Q

endorphins are aka

A

endogenous morphine

47
Q

opioid receptors have effects by changing second messengers like blank

A

cAMP

48
Q

peripheral opioid receptors lead to less activation of these channels which decreases pain

A

calcium, voltage gated sodium

49
Q

pain fibers use a blank kind of sodium channel compared to non pain fibers

A

different

50
Q

can develop after traumatic damage to peripheral nerve and one mechanism is upregulation of sodium channels which leads to more pain

A

causalgia

51
Q

blank projections in spinal cord control how much pain reaches consciousness

A

descending

52
Q

gate control theory can act by this mechanism to reduce pain transmission by releasing endorphin

A

presynaptic

53
Q

gate control theory can work by this mechanism which increases potassium channel activity so the cells are less excitable

A

postsynaptic

54
Q

tens activates this size of axons wherever pain is to inhibit the pain

A

large

55
Q

wide dynamic range of dorsal horn projection cells means that it responds to these inputs`

A

touch, pain

56
Q

repeated or extremely intense painful stimuli can make cns neurons abnormally prone to firing and the synapse becomes stronger

A

central sensitization

57
Q

one mechanism of central sensitization is from extreme activation of blank receptors

A

nmda glutamate receptors

58
Q

pain that does not have a visible cause like phantom limb

A

neuropathic pain

59
Q

fast pain is done by the blank cortex and localizes pain but doesnt tell about the magnitude of the pain

A

somatosensory

60
Q

slow pain is the emotional response to pain and is done here

A

anterior cingulate cortex

61
Q

cannabinoids work via blank receptors and are blank because they work backward and act on the presynaptic cell

A

g protein cannabinoid, retrograde

62
Q

cannibinoids inhibit targest by reducing this channel activity and activating blank channel activity

A

calcium, potassium

63
Q

cannabinoids reduce pain like blank

A

opioids

64
Q

two types of itch

A

chemical, mechanical

65
Q

chemical itch is mediated by blank

A

c fibers

66
Q

mechanical itch is mediated by blank fibers

A

c and a