Lec 5-6 - Adrenal Gland Flashcards
medulla is part of the blank nervous system
sympathetic
cortex is part of the blank system
endocrine
three zones of cortex from outside to inside
zona glomerulosa, fasciculata, reticularis
zone of cortex that makes sex hormones
reticularis
zone of cortex that makes glucocorticoids
fasciculata
zone of cortex that makes aldosterone
glomerulosa
IMPORTANT: the rate limiting step of biosynthesis of adrenal cortical hormones
cholesterol side chain cleavage to form pregnenalone
fasciculata and reticularis have 11, 17, and 21 hydroxylations and 3 dehydrogenations to make these
cortisol, corticosterone
glomerulosa has 11 and 21 hydroxylations, 3 dehydrogenation, and aldosterone synthase makes these
aldosterone
weak androgens that are made
DHEA, androstenedione
aldosterone release is stimulated by these
high plasma K+, increased renin, increased angiotensin, decreased pressure in afferent arteriole, decreased luminal Na+
action of aldosterone
sodium retention, potassium excretion
cortisol action on cns
sense of well being by decreasing sensory acuity
cortisol action on cv system
decrease vascular permeability to water, maintain vasoconstriction, maintain myocardial contractility
cortisol action on kidney
concentrate urine
