Lec 5 - Synaptic Transmission Flashcards
Type of space between electrical synapse
Gap junction
Type of space between chemical synapse
Synaptic cleft
Electrical gap junctions have only blank signals
Excitatory
Chemical signals can be either blank or blank
Excitatory, inhibitory
Channels involved in chemical synapse
Ligand gated
Synapse between neuron and skeletal muscle
Nmj
Large size of nmj ensure high transmission blank
Reliability
Nt at nmj
Ach
Extracellular matrix of nmj contains blank
AchE
This is what has the Ach receptors
Postsynaptic density
Chemical transmission has a blank so it is slower than electrical
Synaptic delay
1 nerve action potential releases 1 blank per active zone which generates a muscle action potential
Quantum
End plate potential is due to blank
Ach receptors
End plate potential at rest is blank
-90 mV
When Ach receptors are activated, there is blank entry in the end plate
Sodium
There is no blank at the peak of the end plate potential
Current
End plate potential always makes a blank
Ap
Curare is an AchR blank which makes it blank to have a MAP
Antagonist, harder
End plate potential is always blank
Excitatory
Inhibiting AchE blank transmitter action
Prolongs
This is involved in the fission of the invaginated clathrin coated endocytosis pits
Dynamin
These activate receptors
Agonists
Curare is a blank antagonists
Nicotinic receptor
Atropine is a blank receptor antagonist
Muscarinic
Nicotinic ionotropic receptors have Ach being blank activated
Directly
Metabotropic muscarinic receptors have Ach being blank activated
Indirectly
Botulinum toxin blocks blank of vesicles
Exocytosis
Alpha bungarotoxin is a venom that blocks blank
Ach
Myasthenia gravis is an autoimmune blank disease that impairs nm transmission by destroying AchRs
Postsynaptic
Lambert eaton myasthenic syndrome is an autoimmune blank disease that impairs nm transmission by destroying Calcium channels
Presynaptic
Process by which neurons send signals to target cells
Synaptic transmission
