Lec 8 - 4 - Acid Base Flashcards
blood pH below 7.35
acidosis
blood pH above 7.45
alkalosis
most acid comes from blank but second is from blank
metabolism, diet
major components of body’s buffering system
CO2, HCO3-
equilibrium toward H+ production
acidosis
equilibrium toward H+ consumption
alkalosis
metabolic pH imbalance is due to changes in blank
HCO3-
respiratory pH imbalance is due to changes in blank
CO2
increased CO2 leads to increased blank
H+
plasma that is adequately ventilated will not have a build up of co2 because it is a blank system
open buffering
lung regulates the blank balance of blood
co2
kidneys control balance of blank
hco3
bicarbonate is the only solute reabsorbed by PT that does not use blank cotransport
sodium
blank happens at apical
H+ secretion
blank happens at basolateral
HCO3- reabsorption
how the kidney prevents from becoming less acidic than 4.4
binds H+ to non HCO3- buffers
nonvolatile buffers
phosphate, creatinine, urate
most commonly used nonvolatile buffer used to bind to H+
phosphate
new hco3 can be derived from blank breadown
glutamine
proximal tubule cannot maximally acidify urine so blank play an important supporting role via blank cells
distal tubule, intercalated
alpha intercalated cells secrete blank
acid
beta intercalated cells secrete blank
base
hyperventilation leads to blank due to blank co2
respiratory alkalosis, decreased
poor ventilation leads to blank due to blank co2
respiratory acidosis, increased
proximal tubule acidosis causes blank and is due to decreased plasma bicarbonate due to mutations of blank
stunted height/weight, blindness, sodium bicarbonate cotransporter
