Lec 6 - More Synaptic Transmission Flashcards
Electric transmission is the only mode of transmission between blank and blank muscle
Smooth, cardiac
Gap junctions are specialized intercellular channels, channel proteins are called blank
Connexons
Excitatory bouton has a thick blank unlike the inhibitory bouton
Postsynaptic density
Cns has no blank which is unlike nmj
Extracellular matrix
These proteins to vesicle recycling at the nerve terminal
Snare
Snare that has synaptobrevin
V snare
Syntaxin and snap 25 use this type of snare
T snare
Calcium sensory involved in vesicle recycling
Synaptotagmin
Fast nt act on blank channels
Ligand gated
Slow nt blank ligand or voltage gated channels
Modulate
Ach, gaba, and glycine receptors have blank subunits and n and c terminals are located blank
5, extracellularly
Glutamine receptors have blank subunits and have n terminal located blank and c located blank
4, extracellularly, intracellularly
Glutamatergic receptor types
Ampa, kainate, nmda
Ampa are permeable to blank and blank which induces an EPP
Sodium, K
Nmda receptors are permeable to these
Sodium, K, Calcium
Nmda receptors trigger more blank intracellular signaling than ampa
Complicated
Ionotropic glutamate receptors
Ampar, nmdar
Metabotropic glutamate receptors
Group 1,2,3
This blocks nmdar at resting membrane potential and is removed by depolarization
Magnesium
Nmda receptorss are involved in blank because it is a synaptic coincidence detector
Learning/memory
Excessive inflow of calcium through nmdar channels
Excitotoxicity
Primary excitatory nt in the cns
Glutamate
Glycinergic receptors are postsynaptic in motor centers of the blank and blank
Spinal cord, brainstem
Gabaergic receptors are postsynaptic in the blank
Brain
Gaba is permeable to blank
Chloride
Glutamate receptors are concentrated at blank
Postsynatpic densities/ distal dendrites (like spines)
Gaba receptors are concentrated at blank
Soma/proximal dendrites
Electrical transmission is more prevalent in the cns before blank
Adulthood
