Immunology- Immunoglobulins, Complement, and Cellular Testing Flashcards
1
Q
- Which of the following symptoms in a young child
may indicate an immunodeficiency syndrome?
A. Anaphylactic reactions
B. Severe rashes and myalgia
C. Recurrent bacterial, fungal, and viral infections
D. Weight loss, rapid heartbeat, breathlessness
A
C. Recurrent bacterial, fungal, and viral infections
2
Q
- What screening test should be performed first in a
young patient suspected of having an immune
dysfunction disorder?
A. Complete blood count (CBC) and white cell
differential
B. Chemotaxis assay
C. Complement levels
D. Bone marrow biopsy
A
A. Complete blood count (CBC) and white cell
differential
3
Q
- Which test should be performed when a patient
has a reaction to transfused plasma products?
A. Immunoglobulin levels
B. T-cell count
C. Hemoglobin levels
D. Red cell enzymes
A
A. Immunoglobulin levels
4
Q
- What is the “M” component in monoclonal
gammopathies?
A. IgM produced in excess
B. μ Heavy chain produced in excess
C. Malignant proliferation of B cells
D. Monoclonal antibody or cell line
A
D. Monoclonal antibody or cell line
5
Q
- A child suspected of having an inherited humoral
immunodeficiency disease is given diphtheria/
tetanus vaccine. Two weeks after the immunization,
his level of antibody to the specific antigens is
measured. Which result is expected for this patient
if he/she indeed has a humoral deficiency?
A. Increased levels of specific antibody
B. No change in the level of specific antibody
C. An increase in IgG-specific antibody but not
IgM-specific antibody
D. Increased levels of nonspecific antibody
A
B. No change in the level of specific antibody
6
Q
- Which disease may be expected to show an IgM
spike on an electrophoretic pattern?
A. Hypogammaglobulinemia
B. Multicystic kidney disease
C. Waldenström’s macroglobulinemia
D. Wiskott–Aldrich syndrome
A
C. Waldenström’s macroglobulinemia
7
Q
- In testing for DiGeorge’s syndrome, what type
of laboratory analysis would be most helpful in
determining the number of mature T cells?
A. Complete blood count
B. Nitroblue tetrazolium (NBT) test
C. T-cell enzyme assays
D. Flow cytometry
A
D. Flow cytometry
8
Q
- Interpret the following description of an
immunofixation electrophoresis assay of urine.
Dense wide bands in both the κ and λ lanes.
No bands present in the heavy-chain lanes.
A. Normal
B. Light chain disease
C. Increased polyclonal Fab fragments
D. Multiple myeloma
A
C. Increased polyclonal Fab fragments
9
Q
- Free monoclonal light chains are often present in
the serum of multiple myeloma patients, and may
be useful for disease monitoring. Which of the
following assays would be recommended to detect
the presence of serum-free light chains?
A. Serum protein electrophoresis
B. Urine immunofixation
C. Nephelometry
D. ELISA
A
C. Nephelometry
10
Q
- What is measured in the CH50 assay?
A. RBC quantity needed to agglutinate 50% of
antibody
B. Complement needed to lyse 50% of RBCs
C. Complement needed to lyse 50% of antibodysensitized RBCs
D. Antibody and complement needed to sensitize
50% of RBCs
A
C. Complement needed to lyse 50% of antibodysensitized RBCs
11
Q
- What type of disorders would show a decrease in
C3, C4, and CH50?
A. Autoimmune disorders such as SLE and RA
B. Immunodeficiency disorders such as common
variable immunodeficiency
C. Tumors
D. Bacterial, viral, fungal, or parasitic infections
A
A. Autoimmune disorders such as SLE and RA
12
Q
- All of the following tests measure phagocyte
function except:
A. Leukocyte adhesion molecule analysis
B. Di Hydro rhodamine reduction assay
C. NBT test
D. IL-2 (interleukin-2) assay
A
D. IL-2 (interleukin-2) assay
