Immunohematology-Genetics and Immunology of Blood Groups Flashcards
1
Q
- What type of serological testing does the blood
bank technologist perform when determining the
blood group of a patient?
A. Genotyping
B. Phenotyping
C. Both genotyping and phenotyping
D. Polymerase chain reaction
A
B. Phenotyping
2
Q
- If anti-K reacts 3+ with a donor cell with a
genotype KK and 2+ with a Kk cell, the antibody
is demonstrating:
A. Dosage
B. Linkage disequilibrium
C. Homozygosity
D. Heterozygosity
A
A. Dosage
3
Q
- Carla expresses the blood group antigens Fya, Fyb,
and Xga. James shows expressions of none of these
antigens. What factor(s) may account for the
absence of these antigens in James?
A. Gender
B. Race
C. Gender and race
D. Medication
A
C. Gender and race
4
Q
- Which of the following statements is true?
A. An individual with the BO genotype is
homozygous for B antigen
B. An individual with the BB genotype is
homozygous for B antigen
C. An individual with the OO genotype is
heterozygous for O antigen
D. An individual with the AB phenotype is
homozygous for A and B antigens
A
B. An individual with the BB genotype is
homozygous for B antigen
5
Q
- Which genotype is heterozygous for C?
A. DCe/dce
B. DCE/DCE
C. Dce/dce
D. DCE/dCe
A
A. DCe/dce
6
Q
- Which genotype(s) will give rise to the Bombay
phenotype?
A. HH only
B. HH and Hh
C. Hh and hh
D. hh only
A
D. hh only
7
Q
- Meiosis in cell division is limited to the ova and
sperm producing four gametes containing what
complement of DNA?
A. 1N
B. 2N
C. 3N
D. 4N
A
A. 1N
8
Q
- A cell that is not actively dividing is said to be in:
A. Interphase
B. Prophase
C. Anaphase
D. Telophase
A
A. Interphase
9
Q
- Which of the following describes the expression of
most blood group antigens?
A. Dominant
B. Recessive
C. Codominant
D. Corecessive
A
C. Codominant
10
Q
- What blood type is not possible for an offspring of
an AO and BO mating?
A. AB
B. A or B
C. O
D. All are possible
A
D. All are possible
11
Q
- The alleged father of a child in a disputed case of
paternity is blood group AB. The mother is group
O and the child is group O. What type of
exclusion is this?
A. Direct/primary/first order
B. Probability
C. Random
D. Indirect/secondary/second order
A
D. Indirect/secondary/second order
12
Q
- If the frequency of gene Y is 0.4 and the frequency
of gene Z is 0.5, one would expect that they should
occur together 0.2 (20%) of the time. In actuality,
they are found together 32% of the time. This is
an example of:
A. Crossing over
B. Linkage disequilibrium
C. Polymorphism
D. Chimerism
A
B. Linkage disequilibrium
13
Q
- In the Hardy–Weinberg formula, p2 represents:
A. The heterozygous population of one allele
B. The homozygous population of one allele
C. The recessive allele
D. The dominant allele
A
B. The homozygous population of one allele
14
Q
- In this type of inheritance, the father carries the
trait on his X chromosome. He has no sons with
the trait because he passed his Y chromosome to
his sons; however, all his daughters will express the
trait.
A. Autosomal dominant
B. Autosomal recessive
C. X-linked dominant
D. X-linked recessive
A
c. X-linked dominant
15
Q
- Why do IgM antibodies, such as those formed
against the ABO antigens, have the ability to
directly agglutinate red blood cells (RBCs) and
cause visible agglutination?
A. IgM antibodies are larger molecules and have the
ability to bind more antigen
B. IgM antibodies tend to clump together more
readily to bind more antigen
C. IgM antibodies are found in greater
concentrations than IgG antibodies
D. IgM antibodies are not limited by subclass
specificity
A
A. IgM antibodies are larger molecules and have the
ability to bind more antigen
