hematology- Qualitative and Quantitative White Blood Cell Disorders

Question 1

1. Which of the following is an unusual complication
   that may occur in infectious mononucleosis?
   A. Splenic infarctions
   B. Dactylitis
   C. Hemolytic anemia
   D. Giant platelets

Answer 1

C. Hemolytic anemia

Question 2

2. In a patient with human immunodeficiency virus
   (HIV) infection, one should expect to see:
   A. Shift to the left in WBCs
   B. Target cells
   C. Reactive lymphocytes
   D. Pelgeroid cells

Answer 2

C. Reactive lymphocytes

Question 3

3. Which inclusions may be seen in leukocytes?
   A. Döhle bodies
   B. Basophilic stippling
   C. Malarial parasites
   D. Howell–Jolly bodies

Answer 3

A. Döhle bodies

Question 4

4. Which of the following is contained in the primary
   granules of the neutrophil?
   A. Lactoferrin
   B. Myeloperoxidase
   C. Histamine
   D. Alkaline phosphatase

Answer 4

B. Myeloperoxidase

Question 5

5. What is the typical range of relative lymphocyte
   percentage in the peripheral blood smear of a
   1-year-old child?
   A. 1%–6%
   B. 27%–33%
   C. 35%–58%
   D. 50%–70%

Answer 5

D. 50%–70%

Question 6

6. Qualitative and quantitative neutrophil changes
   noted in response to infection include all of the
   following except:
   A. Neutrophilia
   B. Pelgeroid hyposegmentation
   C. Toxic granulation
   D. Vacuolization

Answer 6

B. Pelgeroid

Question 7

7. Neutropenia is present in patients with which
   absolute neutrophil counts?
   A. <1.5 × 109/L
   B. <5.0 × 109/L
   C. <10.0 × 109/L
   D. <15.0 × 109/L

Answer 7

A. <1.5 × 109/L

Question 8

8. The morphological characteristic(s) associated
   with the Chédiak–Higashi syndrome is (are):
   A. Pale blue cytoplasmic inclusions
   B. Giant lysosomal granules
   C. Small, dark-staining granules and condensed
   nuclei
   D. Nuclear hyposegmentation

Answer 8

B. Giant lysosomal granules

Question 9

9. The familial condition of Pelger–Huët anomaly is
   important to recognize because this disorder must
   be differentiated from:
   A. Infectious mononucleosis
   B. May–Hegglin anomaly
   C. A shift-to-the-left increase in immature
   granulocytes
   D. G6PD deficiency

Answer 9

C. A shift-to-the-left increase in immature
granulocytes

Question 10

10. SITUATION: A differential shows reactive
    lymphocytes, and the physician suspects a viral
    infection is the cause. What is the expected
    laboratory finding in a patient with a
    cytomegalovirus (CMV) infection?
    A. Heterophile antibody: positive
    B. Epstein–Barr virus (EBV)–immunoglobulin
    (IgM): positive
    C. Direct antiglobulin test (DAT): positive
    D. CMV–IgM: positive

Answer 10

D. CMV–IgM: positive

Question 11

11. Neutrophil phagocytosis and particle ingestion are
    associated with an increase in oxygen utilization
    called respiratory burst. What are the two most
    important products of this biochemical reaction?
    A. Hydrogen peroxide and superoxide anion
    B. Lactoferrin and NADPH oxidase
    C. Cytochrome b and collagenase
    D. Alkaline phosphatase and ascorbic acid

Answer 11

A. Hydrogen peroxide and superoxide anion

Question 12

12. Which of the morphological findings are
    characteristic of reactive lymphocytes?
    A. High nuclear:cytoplasmic ratio
    B. Prominent nucleoli
    C. Basophilic cytoplasm
    D. All of these options

Answer 12

D. All of these options