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***Medical Lab science review- Robert Harr 4th > hematology- Platelet and Vascular Disorders > Flashcards

hematology- Platelet and Vascular Disorders Flashcards

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1
Q
  1. Thrombotic thrombocytopenic purpura (TTP) is
    characterized by:
    A. Prolonged PT
    B. Increased platelet aggregation
    C. Thrombocytosis
    D. Prolonged APTT
A

B. Increased platelet aggregation

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2
Q
  1. Thrombocytopenia may be associated with:
    A. Postsplenectomy
    B. Hypersplenism
    C. Acute blood loss
    D. Increased proliferation of pluripotential stem
    cells
A

B. Hypersplenism

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3
Q
  1. Aspirin prevents platelet aggregation by inhibiting
    the action of which enzyme?
    A. Phospholipase
    B. Cyclo-oxygenase
    C. Thromboxane A2 synthetase
    D. Prostacyclin synthetase
A

B. Cyclo-oxygenase

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4
Q
  1. Normal platelet adhesion depends upon:
    A. Fibrinogen
    B. Glycoprotein Ib
    C. Glycoprotein IIb, IIIa complex
    D. Calcium
A

B. Glycoprotein Ib

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5
Q
  1. Which of the following test results is normal in a
    patient with classic von Willebrand’s disease?
    A. Bleeding time
    B. Activated partial thromboplastin time
    C. Platelet count
    D. Factor VIII:C and von Willebrand’s factor
    (VWF) levels
A

C. Platelet count

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6
Q
  1. Bernard–Soulier syndrome is associated with:
    A. Decreased bleeding time
    B. Decreased factor VIII assay
    C. Thrombocytopenia and giant platelets
    D. Abnormal platelet aggregation to ADP
A

C. Thrombocytopenia and giant platelets

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7
Q
  1. When performing platelet aggregation studies,
    which set of platelet aggregation results would most
    likely be associated with Bernard–Soulier syndrome?
    A. Normal platelet aggregation to collagen, ADP,
    and ristocetin
    B. Normal platelet aggregation to collagen, ADP, and
    epinephrine; decreased aggregation to ristocetin
    C. Normal platelet aggregation to epinephrine and
    ristocetin; decreased aggregation to collagen
    and ADP
    D. Normal platelet aggregation to epinephrine,
    ristocetin, and collagen; decreased aggregation
    to ADP
A

B. Normal platelet aggregation to collagen, ADP, and
epinephrine; decreased aggregation to ristocetin

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8
Q
  1. Which set of platelet responses would be most
    likely associated with Glanzmann’s
    thrombasthenia?
    A. Normal platelet aggregation to ADP and
    ristocetin; decreased aggregation to collagen
    B. Normal platelet aggregation to collagen;
    decreased aggregation to ADP and ristocetin
    C. Normal platelet aggregation to ristocetin;
    decreased aggregation to collagen, ADP, and
    epinephrine
    D. Normal platelet aggregation to ADP; decreased
    aggregation to collagen and ristocetin
A

C. Normal platelet aggregation to ristocetin;
decreased aggregation to collagen, ADP, and
epinephrine

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9
Q
  1. Which of the following is a characteristic of acute
    immune thrombocytopenic purpura?
    A. Spontaneous remission within a few weeks
    B. Predominantly seen in adults
    C. Nonimmune platelet destruction
    D. Insidious onset
A

A. Spontaneous remission within a few weeks

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10
Q
  1. TTP differs from DIC in that:
    A. APTT is normal in TTP but prolonged in DIC
    B. Schistocytes are not present in TTP but are
    present in DIC
    C. Platelet count is decreased in TTP but normal
    in DIC
    D. PT is prolonged in TTP but decreased in DIC
A

A. APTT is normal in TTP but prolonged in DIC

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11
Q
  1. Several hours after birth, a baby boy develops
    petechiae and purpura and a hemorrhagic
    diathesis. The platelet count is 18 × 109/L. What is
    the most likely explanation for the low platelet
    count?
    A. Drug-induced thrombocytopenia
    B. Secondary thrombocytopenia
    C. Neonatal alloimmune thrombocytopenia
    D. Neonatal DIC
A

C. Neonatal alloimmune thrombocytopenia

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12
Q
  1. Which of the following is associated with
    post-transfusion purpura (PTP)?
    A. Nonimmune thrombocytopenia/alloantibodies
    B. Immune-mediated thrombocytopenia/
    alloantibodies
    C. Immune-mediated thrombocytopenia/
    autoantibodies
    D. Nonimmune-mediated thrombocytopenia/
    autoantibodies
A

B. Immune-mediated thrombocytopenia/
alloantibodies

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13
Q
  1. Hemolytic uremic syndrome (HUS) is
    associated with:
    A. Fever, thrombocytosis, anemia, and renal failure
    B. Fever, granulocytosis, and thrombocytosis
    C. Escherichia coli 0157:H7
    D. Leukocytosis and thrombocytosis
A

C. Escherichia coli 0157:H7

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14
Q
  1. Storage pool deficiencies are defects of:
    A. Platelet adhesion
    B. Platelet aggregation
    C. Platelet granules
    D. Platelet production
A

C. Platelet granules

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15
Q
  1. Lumi-aggregation measures:
    A. Platelet aggregation only
    B. Platelet aggregation and ATP release
    C. Platelet adhesion
    D. Platelet glycoprotein Ib
A

B. Platelet aggregation and ATP release

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16
Q
  1. Neurological findings may be commonly
    associated with which of the following disorders?
    A. HUS
    B. TTP
    C. ITP
    D. PTP
A

B. TTP

17
Q
  1. Which of the following is correct regarding
    acquired thrombotic thrombocytopenic purpura?
    A. Autoimmune disease
    B. Decreased VWF
    C. Decreased platelet aggregation
    D. Decreased platelet adhesion
A

A. Autoimmune disease

18
Q
  1. Hereditary hemorrhagic telangiectasia is a
    disorder of:
    A. Platelets
    B. Clotting proteins
    C. Fibrinolysis
    D. Connective tissue
A

D. Connective tissue

19
Q
  1. Which of the following prevents platelet
    aggregation?
    A. Thromboxane A2
    B. Thromboxane B2
    C. Prostacyclin
    D. Antithrombin
A

C. Prostacyclin

20
Q
  1. Which defect characterizes Gray’s syndrome?
    A. Platelet adhesion defect
    B. Dense granule defect
    C. Alpha granule defect
    D. Coagulation defect
A

C. Alpha granule defect

21
Q
  1. The P2Y12 ADP receptor agonist assay may be
    used to monitor platelet aggregation inhibition to
    which of the following drugs?
    A. Warfarin
    B. Heparin
    C. LMWH
    D. Clopidogrel (Plavix)
A

D. Clopidogrel (Plavix)

22
Q
  1. Which of the following instruments can be used to
    evaluate platelet function?
    A. Platelet aggregometer
    B. VerifyNow
    C. PFA-100
    D. All of the above
A

D. All of the above

23
Q
  1. Which of the following platelet aggregating agents
    demonstrates a monophasic aggregation curve
    when used in optimal concentration?
    A. Thrombin
    B. Collagen
    C. Adenosine diphosphate (ADP)
    D. Epinephrine
A

B. Collagen

***Medical Lab science review- Robert Harr 4th (63 decks)

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