hematology- Hypochromic and Microcytic Anemias

Question 1

1. The osmotic fragility test result in a patient with
   thalassemia major would most likely be:
   A. Increased
   B. Decreased
   C. Normal
   D. Decreased after incubation at 37°C

Answer 1

B. Decreased

Question 2

2. All of the following are characteristic findings in a
   patient with iron deficiency anemia except:
   A. Microcytic, hypochromic red cell morphology
   B. Decreased serum iron and ferritin levels
   C. Decreased total iron-binding capacity (TIBC)
   D. Increased RBC protoporphyrin

Answer 2

C. Decreased total iron-binding capacity (TIBC)

Question 3

3. Iron deficiency anemia may be distinguished from
   anemia of chronic infection by:
   A. Serum iron level
   B. Red cell morphology
   C. Red cell indices
   D. Total iron-binding capacity

Answer 3

D. Total iron-binding capacity

Question 4

4. Which anemia has red cell morphology similar to
   that seen in iron deficiency anemia?
   A. Sickle cell anemia
   B. Thalassemia syndrome
   C. Pernicious anemia
   D. Hereditary spherocytosis

Answer 4

B. Thalassemia syndrome

Question 5

5. Iron deficiency anemia is characterized by:
   A. Decreased plasma iron, decreased % saturation,
   increased total iron-binding capacity (TIBC)
   B. Decreased plasma iron, decreased plasma ferritin,
   normal RBC porphyrin
   C. Decreased plasma iron, decreased % saturation,
   decreased TIBC
   D. Decreased plasma iron, increased % saturation,
   decreased TIBC

Answer 5

A. Decreased plasma iron, decreased % saturation,
increased total iron-binding capacity (TIBC)

Question 6

6. Storage iron is usually best determined by:
   A. Serum transferrin levels
   B. Hgb values
   C. Myoglobin values
   D. Serum ferritin levels

Answer 6

D. Serum ferritin levels

Question 7

7. All of the following are associated with
   sideroblastic anemia except:
   A. Increased serum iron
   B. Ringed sideroblasts
   C. Dimorphic blood picture
   D. Increased RBC protoporphyrin

Answer 7

D. Increased RBC protoporphyrin

Question 8

8. What is the basic hematological defect seen in
   patients with thalassemia major?
   A. DNA synthetic defect
   B. Hgb structure
   C. β-Chain synthesis
   D. Hgb phosphorylation

Answer 8

C. β-Chain synthesis

Question 9

9. Which of the following is the primary Hgb in
   patients with thalassemia major?
   A. Hgb D
   B. Hgb A
   C. Hgb C
   D. Hgb F

Answer 9

D. Hgb F

Question 10

10. A patient has an Hct of 30%, a hemoglobin of
    8 g/dL, and an RBC count of 4.0 × 1012/L. What
    is the morphological classification of this anemia?
    A. Normocytic normochromic
    B. Macrocytic hypochromic
    C. Microcytic hypochromic
    D. Normocytic hyperchromic

Answer 10

C. Microcytic hypochromic

Question 11

11. In which of the following conditions is Hgb A2
    elevated?
    A. Hgb H
    B. Hgb SC disease
    C. β-Thalassemia minor
    D. Hgb S trait

Answer 11

C. β-Thalassemia minor

Question 12

12. Which of the following parameters may be similar
    for the anemia of inflammation and iron deficiency
    anemia?
    A. Normocytic indices
    B. Decreased serum iron concentration
    C. Ringed sideroblasts
    D. Pappenheimer bodies

Answer 12

B. Decreased serum iron concentration