Hematology- Macrocytic and Normochromic Anemias

Question 1

1. Which morphological classification is
   characteristic of megaloblastic anemia?
   A. Normocytic, normochromic
   B. Microcytic, normochromic
   C. Macrocytic, hypochromic
   D. Macrocytic, normochromic

Answer 1

D. Macrocytic, normochromic

Question 2

2. Which anemia is characterized by a lack of
   intrinsic factor that prevents B12 absorption?
   A. Tropical sprue
   B. Transcobalamin deficiency
   C. Blind loop syndrome
   D. Pernicious anemia

Answer 2

D. Pernicious anemia

Question 3

3. All of the following are characteristics of
   megaloblastic anemia except:
   A. Pancytopenia
   B. Elevated reticulocyte count
   C. Hypersegmented neutrophils
   D. Macrocytic erythrocyte indices

Answer 3

B. Elevated reticulocyte count

Question 4

4. A patient with a vitamin B12 anemia is given a
   high dosage of folate. Which of the following is
   expected as a result of this treatment?
   A. An improvement in neurological problems
   B. An improvement in hematological abnormalities
   C. No expected improvement
   D. Toxicity of the liver and kidneys

Answer 4

B. An improvement in hematological abnormalities

Question 5

5. Which of the following disorders is associated with
   ineffective erythropoiesis?
   A. G6PD deficiency
   B. Liver disease
   C. Hgb C disease
   D. Megaloblastic anemia

Answer 5

D. Megaloblastic anemia

Question 6

6. A 50-year-old patient is suffering from pernicious
   anemia. Which of the following laboratory data
   are most likely for this patient?

A. RBC = 2.5 × 1012/L; WBC =12,500/μL (12.5 ×
109/L); PLT = 250,000/μL (250 × 109/L)
B. RBC = 4.5 × 1012/L; WBC = 6,500/μL (6.5 ×
109/L); PLT = 150,000/μL (150 × 109/L)
C. RBC = 3.0 × 1012/L; WBC = 5,000/μL (5.0 ×
109/L); PLT = 750,000/μL (750 × 109/L)
D. RBC = 2.5 × 1012/L; WBC = 2,500/μL (2.5 ×
109/L); PLT = 50,000/μL (50 × 109/L)

Answer 6

D. RBC = 2.5 × 1012/L; WBC = 2,500/μL (2.5 ×
109/L); PLT = 50,000/μL (50 × 109/L)

Question 7

7. Which of the following may be seen in the
   peripheral blood smear of a patient with
   obstructive liver disease?
   A. Schistocytes
   B. Macrocytes
   C. Howell–Jolly bodies
   D. Microcytes

Answer 7

B. Macrocytes

Question 8

8. The macrocytes typically seen in megaloblastic
   processes are:
   A. Crescent-shaped
   B. Teardrop-shaped
   C. Ovalocytic
   D. Pencil-shaped

Answer 8

C. Ovalocytic

Question 9

9. Which of the following are most characteristic of
   the red cell indices associated with megaloblastic
   anemias?
   A. MCV 99 fl, MCH 28 pg, MCHC 31%
   B. MCV 62 fL, MCH 27 pg, MCHC 30%
   C. MCV 125 fL, MCH 36 pg, MCHC 34%
   D. MCV 78 fL, MCH 23 pg, MCHC 30%

Answer 9

C. MCV 125 fL, MCH 36 pg, MCHC 34%

Question 10

10. A patient has 80 nucleated red blood cells per 100
    leukocytes. In addition to increased polychromasia
    on the peripheral smear, what other finding may
    be present on the CBC?
    A. Increased platelets
    B. Increased MCV
    C. Increased Hct
    D. Increased red blood cell count

Answer 10

B. Increased MCV