hematology- Lymphoproliferative and Myeloproliferative Disorders Flashcards
1
Q
- Repeated phlebotomy in patients with
polycythemia vera (PV) may lead to the
development of:
A. Folic acid deficiency
B. Sideroblastic anemia
C. Iron deficiency anemia
D. Hemolytic anemia
A
C. Iron deficiency anemia
2
Q
- In essential thrombocythemia, the platelets are:
A. Increased in number and functionally abnormal
B. Normal in number and functionally abnormal
C. Decreased in number and functional
D. Decreased in number and functionally abnormal
A
A. Increased in number and functionally abnormal
3
Q
- Which of the following cells is considered
pathognomonic for Hodgkin’s disease?
A. Niemann–Pick cells
B. Reactive lymphocytes
C. Flame cells
D. Reed–Sternberg cells
A
D. Reed–Sternberg cells
4
Q
- In myelofibrosis, the characteristic abnormal red
blood cell morphology is that of:
A. Target cells
B. Schistocytes
C. Teardrop cells
D. Ovalocytes
A
C. Teardrop cells
5
Q
- PV is characterized by:
A. Increased plasma volume
B. Pancytopenia
C. Decreased oxygen saturation
D. Absolute increase in total red cell mass
A
D. Absolute increase in total red cell mass
6
Q
- Features of secondary polycythemia include all of
the following except:
A. Splenomegaly
B. Decreased oxygen saturation
C. Increased red cell mass
D. Increased erythropoietin
A
A. Splenomegaly
7
Q
- The erythrocytosis seen in relative polycythemia
occurs because of:
A. Decreased arterial oxygen saturation
B. Decreased plasma volume of circulating blood
C. Increased erythropoietin levels
D. Increased erythropoiesis in the bone marrow
A
B. Decreased plasma volume of circulating blood
8
Q
- In PV, what is characteristically seen in the
peripheral blood?
A. Panmyelosis
B. Pancytosis
C. Pancytopenia
D. Panhyperplasia
A
B. Pancytosis
9
Q
- The leukocyte alkaline phosphatase (LAP) stain on
a patient gives the following results
10(0) 48(1+) 38(2+) 3(3+) 1(4+)
Calculate the LAP score.
A. 100
B. 117
C. 137
D. 252
A
C. 137
10
Q
- CML is distinguished from leukemoid reaction by
which of the following?
A. CML: low LAP; leukemoid: high LAP
B. CML: high LAP; leukemoid: low LAP
C. CML: high WBC; leukemoid: normal WBC
D. CML: high WBC; leukemoid: higher WBC
A
A. CML: low LAP; leukemoid: high LAP
11
Q
- Which of the following occurs in idiopathic
myelofibrosis (IMF)?
A. Myeloid metaplasia
B. Leukoerythroblastosis
C. Fibrosis of the bone marrow
D. All of these options
A
D. All of these options
12
Q
- What influence does the Philadelphia (Ph1)
chromosome have on the prognosis of patients
with chronic myelocytic leukemia?
A. It is not predictive
B. The prognosis is better if Ph1 is present
C. The prognosis is worse if Ph1 is present
D. The disease usually transforms into AML when
Ph1 is present
A
B. The prognosis is better if Ph1 is present
13
Q
- Which of the following is (are) commonly found
in CML?
A. Many teardrop-shaped cells
B. Intense LAP staining
C. A decrease in granulocytes
D. An increase in basophils
A
D. An increase in basophils
14
Q
- In which of the following conditions does LAP
show the least activity?
A. Leukemoid reactions
B. Idiopathic myelofibrosis
C. PV
D. CML
A
D. CML
15
Q
- A striking feature of the peripheral blood of a
patient with CML is a:
A. Profusion of bizarre blast cells
B. Normal number of typical granulocytes
C. Presence of granulocytes at different stages of
development
D. Pancytopenia
A
C. Presence of granulocytes at different stages of
development