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***Medical Lab science review- Robert Harr 4th > hematology- Lymphoproliferative and Myeloproliferative Disorders > Flashcards

hematology- Lymphoproliferative and Myeloproliferative Disorders Flashcards

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USMLE® Step 1 flashcards Biology 101 flashcards
1
Q
  1. Repeated phlebotomy in patients with
    polycythemia vera (PV) may lead to the
    development of:
    A. Folic acid deficiency
    B. Sideroblastic anemia
    C. Iron deficiency anemia
    D. Hemolytic anemia
A

C. Iron deficiency anemia

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2
Q
  1. In essential thrombocythemia, the platelets are:
    A. Increased in number and functionally abnormal
    B. Normal in number and functionally abnormal
    C. Decreased in number and functional
    D. Decreased in number and functionally abnormal
A

A. Increased in number and functionally abnormal

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3
Q
  1. Which of the following cells is considered
    pathognomonic for Hodgkin’s disease?
    A. Niemann–Pick cells
    B. Reactive lymphocytes
    C. Flame cells
    D. Reed–Sternberg cells
A

D. Reed–Sternberg cells

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4
Q
  1. In myelofibrosis, the characteristic abnormal red
    blood cell morphology is that of:
    A. Target cells
    B. Schistocytes
    C. Teardrop cells
    D. Ovalocytes
A

C. Teardrop cells

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5
Q
  1. PV is characterized by:
    A. Increased plasma volume
    B. Pancytopenia
    C. Decreased oxygen saturation
    D. Absolute increase in total red cell mass
A

D. Absolute increase in total red cell mass

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6
Q
  1. Features of secondary polycythemia include all of
    the following except:
    A. Splenomegaly
    B. Decreased oxygen saturation
    C. Increased red cell mass
    D. Increased erythropoietin
A

A. Splenomegaly

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7
Q
  1. The erythrocytosis seen in relative polycythemia
    occurs because of:
    A. Decreased arterial oxygen saturation
    B. Decreased plasma volume of circulating blood
    C. Increased erythropoietin levels
    D. Increased erythropoiesis in the bone marrow
A

B. Decreased plasma volume of circulating blood

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8
Q
  1. In PV, what is characteristically seen in the
    peripheral blood?
    A. Panmyelosis
    B. Pancytosis
    C. Pancytopenia
    D. Panhyperplasia
A

B. Pancytosis

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9
Q
  1. The leukocyte alkaline phosphatase (LAP) stain on
    a patient gives the following results
    10(0) 48(1+) 38(2+) 3(3+) 1(4+)
    Calculate the LAP score.
    A. 100
    B. 117
    C. 137
    D. 252
A

C. 137

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10
Q
  1. CML is distinguished from leukemoid reaction by
    which of the following?
    A. CML: low LAP; leukemoid: high LAP
    B. CML: high LAP; leukemoid: low LAP
    C. CML: high WBC; leukemoid: normal WBC
    D. CML: high WBC; leukemoid: higher WBC
A

A. CML: low LAP; leukemoid: high LAP

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11
Q
  1. Which of the following occurs in idiopathic
    myelofibrosis (IMF)?
    A. Myeloid metaplasia
    B. Leukoerythroblastosis
    C. Fibrosis of the bone marrow
    D. All of these options
A

D. All of these options

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12
Q
  1. What influence does the Philadelphia (Ph1)
    chromosome have on the prognosis of patients
    with chronic myelocytic leukemia?
    A. It is not predictive
    B. The prognosis is better if Ph1 is present
    C. The prognosis is worse if Ph1 is present
    D. The disease usually transforms into AML when
    Ph1 is present
A

B. The prognosis is better if Ph1 is present

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13
Q
  1. Which of the following is (are) commonly found
    in CML?
    A. Many teardrop-shaped cells
    B. Intense LAP staining
    C. A decrease in granulocytes
    D. An increase in basophils
A

D. An increase in basophils

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14
Q
  1. In which of the following conditions does LAP
    show the least activity?
    A. Leukemoid reactions
    B. Idiopathic myelofibrosis
    C. PV
    D. CML
A

D. CML

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15
Q
  1. A striking feature of the peripheral blood of a
    patient with CML is a:
    A. Profusion of bizarre blast cells
    B. Normal number of typical granulocytes
    C. Presence of granulocytes at different stages of
    development
    D. Pancytopenia
A

C. Presence of granulocytes at different stages of
development

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16
Q
  1. Which of the following is often associated with
    CML but not with AML?
    A. Infections
    B. WBCs greater than 20.0 × 109/L
    C. Hemorrhage
    D. Splenomegaly
A

D. Splenomegaly

17
Q
  1. Multiple myeloma and Waldenström’s
    macroglobulinemia have all the following in
    common except:
    A. Monoclonal gammopathy
    B. Hyperviscosity of the blood
    C. Bence–Jones protein in the urine
    D. Osteolytic lesions
A

D. Osteolytic lesions

18
Q
  1. What is the characteristic finding seen in the
    peripheral smear of a patient with multiple
    myeloma?
    A. Microcytic hypochromic cells
    B. Intracellular inclusion bodies
    C. Rouleaux
    D. Hypersegmented neutrophils
A

C. Rouleaux

19
Q
  1. All of the following are associated with the
    diagnosis of multiple myeloma except:
    A. Marrow plasmacytosis
    B. Lytic bone lesions
    C. Serum and/or urine M component (monoclonal
    protein)
    D. Philadelphia chromosome
A

D. Philadelphia chromosome

20
Q
  1. Multiple myeloma is most difficult to distinguish
    from:
    A. Chronic lymphocytic leukemia
    B. Acute myelogenous leukemia
    C. Benign monoclonal gammopathy
    D. Benign adenoma
A

C. Benign monoclonal gammopathy

21
Q
  1. The pathology of multiple myeloma includes
    which of the following?
    A. Expanding plasma cell mass
    B. Overproduction of monoclonal
    immunoglobulins
    C. Production of osteoclast activating factor (OAF)
    and other cytokines
    D. All of these options
A

D. All of these options

22
Q
  1. Waldenström’s macroglobulinemia is a
    malignancy of the:
    A. Lymphoplasmacytoid cells
    B. Adrenal cortex
    C. Myeloblastic cell lines
    D. Erythroid cell precursors
A

A. Lymphoplasmacytoid cells

23
Q
  1. Cells that exhibit a positive stain with acid
    phosphatase and are not inhibited with tartaric
    acid are characteristically seen in:
    A. Infectious mononucleosis
    B. Infectious lymphocytosis
    C. Hairy cell leukemia
    D. T-cell acute lymphoblastic leukemia
A

C. Hairy cell leukemia

24
Q
  1. The JAK2(V617F) mutation may be positive in
    all of the following chronic myeloproliferative
    disorders except:
    A. Essential thrombocythemia
    B. Idiopathic myelofibrosis
    C. PV
    D. CML
A

D. CML

25
Q
  1. All of the following are major criteria for the
    2008 WHO diagnostic criteria for essential
    thrombocythemia except:
    A. Platelet count >450 × 109/L
    B. Megakaryocyte proliferation with large and
    mature morphology, and no or little granulocyte
    or erythroid proliferation
    C. Demonstration of JAK2(V617F) or other clonal
    marker
    D. Sustained platelet count >600 × 109/L
A

D. Sustained platelet count >600 × 109/L

***Medical Lab science review- Robert Harr 4th (63 decks)

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