Gastrointestinal: proton pump inhibitors

Question 1

proton pump inhibitors moa

Answer 1

block basal and stimulated acid production, and ruduce gastric acid secretion by irreversibly inhibiting the enzyme that produces gastric acid

Question 2

proton pump inhibitors therapeutic uses

Answer 2

short term gastric and duodenal ulcers, erosive esophagitis, and GERD approved treatment for hypercecretory conditions. Prevention of stress ulcers

Question 3

proton pump inhibitors common meds

Answer 3

• omeprazole
• pantoprazole
• dexlansoprazole
• esomeprazole
• rabeprazole

Question 4

proton pump inhibitors complications

Answer 4

-minor with short term treatment: n/v/d headache

long term treatment:
Pneumonia
osteoporosis and fractures 
rebound acid
hyper secretion 
hypomagnyssium 
c-diff diarrhea

Question 5

proton pump inhibitors contraindications

Answer 5

• hypersensivity
• caution in children and its with dysphagia or liver disease
• caution with those with increased risk for pneumonia

Question 6

proton pump inhibitors interactions

Answer 6

• digoxin, methotrexate, diazepam, tacrolimus, anti fungal agents and phenytoin levels can increase when used with omeprazole
• ketocanazole, intraconazole, atazanavir (decreased beneficial effects)

Question 7

proton pump inhibitors nursing implications

Answer 7

• do not crush, chew or break sustained- release capsules
• do not open capsule and sprinkle contents over food
• pantoprazole can be given iv (risk for thrombophlebitis)

Question 8

proton pump inhibitors pt. teaching

Answer 8

• take omeprazole once per day before meals
• active ulcers should be treated for 4-6 weeks
• notify your provider if you experience coffee-ground emesis