cardio: HMG- coa reductase inhibitors (statins)

Question 1

HMG- CoA reductase inhibitors (statins) moa

Answer 1

• decrease manufacture of LDL and VLDL cholesterol
• can lower triglycerides
• increase manufacture of HDL
• promotion of vasodilation
• decrease in plaque site inflammation, thromboembolism, and risk of atrial fibrillation

Question 2

common statins

Answer 2

• atroastatin
• simvastatin
• lovastatin
• pravastatin
• rosuvastatin
• fluvastatin
• pitavastatin
• simvastatin and ezetimibe

Question 3

statins used for

Answer 3

• hypercholesterolemia

- CAD

Question 4

statins onset, peak, duration, routes

Answer 4

onset: unkown- 1-2 weeks
peak: unkown- 2-6 weeks
duration: unkown 6 weeks
routes: PO

Question 5

statin complications

Answer 5

• hepatoxicity

- myopathy

Question 6

statin contraindications

Answer 6

• liver disorder
• rosauvastain should be avoided for clients of asian descent
• pregnancy category x

Question 7

statin interactions

Answer 7

• fibrates
• hiv protease inhibitors
• amiodarone
• cyclosporine
• grapefruit juice