antimicrobials: antifungals

Question 1

antifungals moa

Answer 1

disrupts fungal cell membranes to cause cell death. can be either fungistatic or fungicidal (depending on dosage)

Question 2

antifungals therapeutic uses

Answer 2

systemic fungal infections or superficial fungal infections

Question 3

antifungals common meds

Answer 3

• amphotericin B
• ketoconazole
• nystatin
• clotrimazole
• fluconazole

Question 4

antifungals complications

Answer 4

• iv infusion reactions (fever, chills, rigors, and headache 1-3 hrs after infusion)
• thrombophlebitis
• nephrotoxicity
• electrolyte imbalance
• bone marrow suppression

Question 5

antifungals contraindications

Answer 5

• impaired kidney function

- caution with anemia, electrolyte imbalance, and bone marrow suppression

Question 6

antifungals interactions

Answer 6

• aminoglycosides (additive nepronotoxic effect)

- azaleas increase levels of digoxin, warfarin, and sulfonylurea antidiabetic meds

Question 7

antifungals nursing implications

Answer 7

• obtain specimens before starting anitfungal therapy
• amphotericin B- highly toxic use only on deadly fungal infections; monitor kidney function
• assess iv site for pain/redness/swelling
• monitor BUN and creatinine, BMP (especially potassium)
• monitor CBC- hematocrit

Question 8

antifungals pt. teaching

Answer 8

• finish entire course of therapy, even if you feel better
• use back up birth control
• use a probiotic or eat yogurt