Cardio: beta blokers

Question 1

Beta blockers MOA

Answer 1

• for cardiac conditions; beta-adrenergic blockers work on beta 1 receptors in the myocardium and in the electrical conduction system of the heart
• alpha blockade ( in peripheral arteries) cause vasodilation, also reduces the release of renin which decreases angiotensin 2 and causes vasodilation/ excretion of sodium and water

Question 2

beta 1 selective meds

Answer 2

metoprolo
atenolol
esmolol

Question 3

non selective (affect both beta 1 and beta 2 receptors)

Answer 3

propranolol

nadolol

Question 4

alpha and beta blockers

Answer 4

carvedilol

labetalol

Question 5

beta-blockers onset peak duration routes antidote

Answer 5

onset: Po 30-60 min,IV 5-15 min
peak: varies on med
duration: varies on med
routes: PO, Iv
antidote: glucagon

Question 6

beta blockers theraputic effects

Answer 6

• decrease heart rate
• decrease blood pressure
• decrease electrical conduction rate in the heart
• depending on med- increases vasodilation

Question 7

beta blockers used for

Answer 7

• hypertension
• angina, tachydysrhythmias, heart failure and MI
• suppresses reflex tachycardia due to vasodilators
• off label- treats hyperthyroidism, migraine, headache, pheochromocytoma, glacoma, anxiety

Question 8

beta blockers complications

Answer 8

• bradycardia
• orthostatic hypotension
• decreased cardiac output
• heart block
• non- selective: bronchoconstriction, inhibited glycogenesis

Question 9

beta blockers contraindications

Answer 9

• heart block or sinus bradycardia
• asthma, bronchospasm, heart failure (non selective beta blockers)
• caution with myasthenia gravis, hypotension, PVD, DM, depression, serve alergies

Question 10

beta blockers interactions

Answer 10

• verapamil and diltiazem (intensifies effects of beta blockers)
• other antihypertensive