cardio: angiotensin 2 receptor (ARB)

Question 1

angiotensin 2 receptor blockers (ARB) moa

Answer 1

• block the action of angiotension 2 in the body, which results in vasodilation (atrioles and veins) and excretion of sodium and water (by decreasing release of aldosterone)

Question 2

common angiotensin 2 receptors (ARB)

Answer 2

losartan
irbesartan
candesartan
olmesartan
telmisartan

Question 3

arbs onset, peak, duration, routes

Answer 3

onset: unknown- in 2 eeks
peak: unknown
duration: 4-6 weeks
routes: PO

Question 4

arbs used for

Answer 4

• hypertension
• heart failure
• stroke prevention (losartan only)
• delay progression of diabetic neuropathy (irbesartan and losartan only)
• protect against Mi, stroke, death from cardiac causes for people who cannot tolerate ACE inhibitors (telmisartan only)

Question 5

arbs complications

Answer 5

complications

• angioedema
• hypotension
• dizziness, lightheadedness

Question 6

contraindications

Answer 6

• bilateral renal stenosis or single kidney

- use cautiously in pt who had angioedma with ace inhibitors

Question 7

interactions

Answer 7

• other antihypertensive medications

- lithium