cardio: organic nitrates

Question 1

organic nitrates moa

Answer 1

• increases coronary blood flow by dilating coronary arteries and improving collateral flow to ischemic regions
• produces vasodilation (venous greater than arterial)
• decreases preload
• reduces myocardial oxygen consumption

Question 2

common nitrates

Answer 2

• nitroglycerin
• isosorbide dinitrate
• isosorbide mononitrate

Question 3

common nitrates used for

Answer 3

• angina pectoris
• CHF
• MI

Question 4

nitrates onset, peak, duration, routes

Answer 4

onset: depends on route
peak: unkown
duration: varies
routes: Sl, buccal, Po, transdermal, IV

Question 5

nitrates complications

Answer 5

• orthostatic hypotension
• headache
• reflex tachycardia
• tolerance

Question 6

common nitrates side effects

Answer 6

• diziness
• hypotension
• headahce
• weakness
• blurred vision

Question 7

nitrates contraindications

Answer 7

• hypersensitivity to nitrates
• severe anemia
• closed-angel glaucoma
• traumatic head injury
• cautiously with other antihypertensive, hyperthyroidism, kidney or liver dysfunction
• inhibits of phosphodiesterase type 5 (for ED)- can cause life threating hypotension

Question 8

nitrates interactions

Answer 8

• alcohol
• antihypertensives
• sildenafil