Gastrointestinal: Histamine 2- receptor antagonists

Question 1

Histamine 2- receptor antagonists MOA

Answer 1

H2 receptors which suppress secretion of gastric acid and lowers the concentration oh hydrogen ions in the stomach

Question 2

Histamine 2- receptor antagonists therapeutic uses

Answer 2

treatment and gastric and duodenal ulcers, gerd, hypersecretory condition, management of urticaria

Question 3

Histamine 2- receptor antagonists common meds

Answer 3

• ranitidine (not on market anymore)
• cimetidine
• famotidine
• nizatidine (po only)

Question 4

Histamine 2- receptor antagonists complications

Answer 4

• blocked androgen receptors

- CNS effects (lethargy, hallucinations, confusion, restlessness)

Question 5

Histamine 2- receptor antagonists contrainindications

Answer 5

• caution with older adults (may have increased adverse effects)
• caution with clients at high risk for pneumonia , including COPDers

Question 6

Histamine 2- receptor antagonists interactions

Answer 6

• warfarin, phenytoin, theophylline, and lidocaine (risk or increased levels in the blood)
• concurrent use of antacids can decrease absorption of h2 antagonist
• smoking (decreases effectiveness)

Question 7

Histamine 2- receptor antagonists nursing implications

Answer 7

• famotidine can be given iv in acute situations
• teach clients that smoking should be avoided
• encourage clients who are symptomatic to see gi specialist
• treatment starts with x2 daily, then tapered to 1x daily usually at hs

Question 8

Histamine 2- receptor antagonists pt. teaching

Answer 8

• treatments starts with 2 doses a day then when ulcer is healed once a day at night time
• smoking cessation teaching
• avoid alcohol
• limit foods that cause gi irritation
• notify your provider if you see coffee ground emeis
• limit use of aspirin and other nsaids
• increase fiber and fluids to help constipation
• no overeatting, stress, smoking, NSAIDS