gastrointestinal: antimetics- serotonin antagonist and dopamine antagonists

Question 1

antimetics serotonin antagonist and dopamine antagonists moa

Answer 1

serotonin antagonist- prevents emesis by blocking the serotonin receptors in the chemoreceptors trigger zone (CTZ) and antagonizing the serotonin receptors on the afferent vagal neurons that travel from the upper gi tract to the coz

dopamine antagonist- antiseptic effects result from blockage of dopamine receptors in the ctz

Question 2

antimetics serotonin antagonist and dopamine antagonists therapeutic uses

Answer 2

prevents emesis related to chemotherapy, toxins, and postoperative surgery

Question 3

antimetics serotonin antagonist and dopamine antagonists common meds

Answer 3

S.A: ondansetron (zofran)- PO, Im, IV

D.A: prochlorperazine (compagnie
metoclopramide (reglan)
promethazine (phenergan)
po, im, pr, iv)

Question 4

antimetics serotonin antagonist and dopamine antagonists complications for S.A

Answer 4

• headaches, diarrhea, dizziness
• prolonged QT interval (can lead to serious dysrhythmia)
• serotonin syndrome (rare)

Question 5

antimetics serotonin antagonist and dopamine antagonists D.A

Answer 5

• extrapyramidal symtoms

- hypotension, sedation, dry mouth, urinary, retention/ constipation

Question 6

antimetics serotonin antagonist and dopamine antagonists contraindications

Answer 6

• caution with older adults, urinary retention, narrow angle glaucoma, gi bleeds

Question 7

antimetics serotonin antagonist and dopamine antagonists interactions

Answer 7

• cns depressants

- antihypertensives

Question 8

antimetics serotonin antagonist and dopamine antagonists nursing implications

Answer 8

• gi assesment needed prior to admin
• monitor for prolonged qt (heart palpitations)
• monitor for sedation/ hypotension

Question 9

antimetics serotonin antagonist and dopamine antagonists pt. teaching

Answer 9

• take as directed

- notify your provider if having irregular heart beat, or involuntary muscle movements