extra Flashcards
what endocrine tissue does GH work on and what does this release
liver
IGF1
3 LAYERS OF ADRENAL CORTEX
zona glomerulosa
zona fasiculata
zona reticularis
secretes steroids
adrenal cortex
secretes catecholamines
adrenal medulla
formed from neural ectoderm
adrenal medulla
formed from medoderm
adrenal cortex
what secretes cortisol and androgesn
ZFR- zones fasiculata and reticularis
how does blood flow in adrenal cortex
out to in
angtiotensin, K and ACTH purpose
SCC enzyme inducing
what does SCC produces
DHEA which produces steroid hormones
upregulates LDL receptors
ACTH in all 3 zones
what do tropic hormones do
stimulate and maintain cellualar growth of their target endocrine tissues
atrophy or hypertrophy
catabolic steroid
cortisol
androgens- anabolic or catabolic
anabolic
what causes secretion of cortisol
stress and dinural rhythm
permissive for catecholamines
cortisol
when does hemmorage occur
in absence of cortisol which is permissive for catecholamines which cuase constriction of blood vessels
what does cortisol protective during
ACUTE stress
primary insufficiency of addisons disease
adrenal cortex destroyed by autoimmune action
other hormones secreted during stress
cortisol, ADH, glucagon, epinephrine, aldosterone, GH
what displays synergysm
glycagon, cotisol, epinephrine
inc blood glucose
where are c cells
in thyroid
what enzyme is needed for thyroid hormone production
thyroid peroxidase
MIT
tyrosine and I
supply of thyroid hormones
2-3 months
bioactive forms of thyroid hormones
free T3 and T4 in eqm with bound TBG
where does deiodination of T4 take place
liver and kidney
biological activity features of thyroid hormones
BMR (inc with hyperthyroidism)
growth and development
CNS developemnt and function
low mental age with hypothyroidism
essential for mentation
enhances SNS activity- inc catecholamine receotrs
inc speed of nervous reflexes
has sympathomimetic activity
thyroid hormones
hypothyroidism
low secreiton of thyroid hormones
hypothyroidism due to
autoimmune- thyroditis and subsequent fibrosis and low TSH and TRH
hypothyroidism due to
autoimmune- thyroditis and subsequent fibrosis and low TSH and TRH
low iodine
hyperthyroidism due to
autoimmune- graves disease or thyrotoxicosis- TSI stimulates TSH receptors
thyroid tumor
excess TSH or TRH
when does myxedemia happen
hypothyroidism
what is myxedemia
puffy doughy appearance
causes elevated blood cholesterol
hypothyroidism
what causes exophthalamos
hyperthyroidism
