extra Flashcards

1
Q

heart and CNS

A

no direct connection to CNS

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2
Q

heart phosphorylation type

A

oxidative

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3
Q

what drives SA node AP

A

ca

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4
Q

what drives atria and ventricle AP

A

Na

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5
Q

what are gap junctions present within

A

intercalated disks

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6
Q

what are gap junctions

A

protein tunnels that connect cytoplasm ofadjascent cells and transmit depolarization

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7
Q

what cells cant contract in the heart

A

the cells in the conducting system

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8
Q

what increases force of ventricle contraction

A

more calcium release

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9
Q

what does M2 do in heart

A

hyperpolarizes SA node cells and reduces node firing

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10
Q

starlings law of the heart

A

more blood more contraction and ejection and better way the actin and myosin sit with each other

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11
Q

where do sensory afferent axons cross

A

at the across midbrain

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12
Q

what does the sensory afferent axon join once it enters spinal chord dorsal horn

A

dorsla column of white matter

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13
Q

whre does the axon from the periphery make its first synapse

A

at the medulla

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14
Q

condition where you dont feel pain

A

congenital analgesia

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15
Q

what is used as a transmitter in the pain pathway

A

glutamate in NMDA receptor

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16
Q

what is used as a neuromodulator in pain pathways

A

substance P

17
Q

two pain neurotramsittesr

A

substance P and glutamate

18
Q

what controls pain related behaviour such as vocalization

A

brainstem sites

19
Q

what is especially activated by pain information

A

the cinguiate cortex

20
Q

sensitizes dorsal horn afferents

A

glutamate

21
Q

skeletal muscle reflex sensory receptors

A

muscle sipndle
golgi tendon organ
joint receptors

22
Q

feedback of stretch reflec

A

negative feedback
efferent signals to shorten muscle and decrease firing rate of snesory

23
Q

what neurons in stretch reflex

A

a motor neurons

24
Q

what is stimulated in isotonic contraction

A

a motor neurons

25
Q

modulates sensitivity of spindles

A

gamma motor neurons

26
Q

what is activated in CNS during voluntary movement

A

a and gamma motor neurons

27
Q

what restores sensitivtity of spindles

A

rapid contraction of intrafusal fibres increases tension on central sensory element of spindles

28
Q

what causes an increase in the firing of spindle afferents

A

length change

29
Q

what happens in isometric contraction

A

a motor neuron stimulated
resnion inc but length is same so no inc in firing

tension transferred to GTO, the afferents of whos increase firing

30
Q

muscle disease

A

interruption of reflex arc by either peripheral sensory or lower motor neuron lesion

31
Q

what does injury of UMN above anterior horn cell lead to

A

loss of descending inhibition

32
Q

spasticity

A

increaed reflex and muscle tone

33
Q

what is above anterior horn cell

A

spinal chord, brain stem, motor cortex

34
Q

LMN injury

A

hyporeflexia- no strethc reflex and no muscle tone due to loss of innervation to muscle

35
Q

UMN injusry

A

inc muscle tone
hyperreflexia

36
Q

effector neuron in spinal chord

A

LMN

37
Q

neurons in higher brain levels that influenve neruson in spinal chord

A

UMN