[C] 1.64 Granulomas caused by chemicals and other granulomas

Question 1

Endogenous chemical substances causing granuloma

Answer 1

• Cholesterol
• Urate salts
• Calcium salts
• Mucous

Question 2

Exogenous chemical substances causing granuloma

Answer 2

• Aluminium hydroxide
• Oil
• Paraffin (paraffinoma)
• Vaseline (Vaselinoma)
• Talcum

Question 3

What type of granuloma is normally caused by chemicals?

Answer 3

Connective tissue type

Question 4

Cholesterol granuloma may be found…

Answer 4

• Brain
• Blood vessels (Atheroma)

Question 5

Urate granuloma

Answer 5

Tophus

Identified with the Schultz-Smith reaction (Crystals become green)

Question 6

Mucous granuloma

Answer 6

Mucocele

Question 7

Aluminium hydroxide granuloma: Native preparation

Answer 7

• Al(OH)₃ granules resembling plant fibres
• In the cytoplasm of the proliferating histiocytes

Question 8

Aluminium-hydroxide granuloma: Demonstration

Answer 8

• Following morin-treatment
  
  • Yellow-green fluorescence in UV light
• Aluminon reaction:
  
  • Aurin-tricarbonic-ammonium salt stains it red

Question 9

Granuloma caused by oil

Answer 9

Oleogranuloma

Question 10

Granuloma caused by other chemical substances

Answer 10

• Talcum granuloma
• Granuloma caused by plant fibres
• Granuloma caused by ingrown hair
• Pneumoconiosis induced granulomas
  
  • Coal dust
  • Silicates
  • Asbestos