[A] 1.18 Local oligaemia (ischaemia) Flashcards

1
Q

Ischaemia

A

Local inadequate blood supply

  • General:
    • Anaemia
    • Hypovolaemia
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2
Q

Physiological ischaemia

A
  • Digestion
  • Uneven distribution of blood
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3
Q

Pathological ischaemia

A
  • Compression
  • Obturation
  • Vasoneurotic disturbances
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4
Q

Ischaemia compressiva

A
  • Tympany (horse, cow, rabbit)
  • Tumours
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5
Q

Ischaemia obturativa

A
  • Thrombus
  • Embolus
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8
Q

Vasoneurotic ischaemia

A

Angiospasm

CNS, cold, chemicals

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9
Q

The consequences of ischaemia depends on…

A
  • Degree and type of narrowing
  • Time
  • Type of tissue
  • Collaterals (Lung, liver)
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10
Q

How the tissue type alters the impact of an infarction

A
  1. End arteries → No anastomotic channel → Infarct
  2. Anastomotic arteries → Blood flow can still occur (Kidneys)
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11
Q

Give the consequences of ischaemia

A
  • Collapse/shock
  • Necrosis:
    • Infarctus haemorrhagicus
    • Infarctus ischaemicus
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12
Q

Infarction: Definition

A

Necrosis of circumscribed area of tissue due to acute ischemia

Vessels are obturated

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14
Q

Ischemic infarction: End arteries

  • Appearance
A
  • Area becomes bloodless, necrotic
  • Appearance:
    • Pale grey, dry
    • Margin of infarction is reddish
      • The collateral vessels are full with RBCs
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15
Q

Locations of ischemic infarction

A
  • Kidneys
  • Heart
  • Spleen
  • Brain
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16
Q

Formation of the infarction

A
  • Pale, swollen, no sharp edges
  • Histochemical methods are needed for demonstration
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17
Q

Haemorrhagic infarction

A

Double circulation

  • In the necrotic area, the vessels are filled with RBCs
  • Red (darker), dry
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18
Q

Fresh infarction: appearance

A
  • Cone shaped
  • Pale
  • Enlarged
  • Sharp edged
  • Cut surface is still moist
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19
Q

Evolved infarction: Appearance

A
  • Cur surface dry
  • Homogenous
  • Crumbled
  • Dark red
  • Hyperaemic rim
20
Q

Older/chronic infarction: appearance

A

Surrounded by demarcation zone, scar

22
Q

Haemorrhagic infarction: Location

A
  • Lungs
  • Kidney
  • Spleen
  • Liver
23
Q

List the factors impacting on infarction

A
  • Nature of vascular supply
  • Rate of occlusion development
  • Vulnerability to hypoxia
  • Oxygen content of the blood
24
Q

Nature of vascular supply: Factor of infarction

A
  • Double (lungs, liver)
  • End-arterial (kidney, spleen)
25
Q

Rate of occlusion development: Effect of infarction

A

If it is slow, collateral blood supply may develop

26
Q

Vulnerability to hypoxia: Impact on infarction

A
  • Neurons = 3-4 mins
  • Myocardial cells = 20-30 mins
  • Fibroblasts = Hours
27
Q

Give the consequences of an infarction

A
  • Death
    • Insufficient heart & lung supply/function
  • Survival
    • Reactive inflammation
    • Repair
    • Organisatio - Connective tissue