[C] 1.32 Pathologic pigmentation caused by hemoglobin and haemosiderin

Question 1

Haemolysis →

Answer 1

Haemoglobinaemia

Question 2

Give the causes of haemolysis

Answer 2

• Autointoxication
• Chemicals
• Drugs
• Physical effects
• Pathogens
• Plant poisons

Question 3

Hemosiderin

Answer 3

• Brown, amorphus, granular, iron-containing pigemnt
• Develops in RES macrophages
• Siderin: Injection of iron-dextrant preparates
• Local haemorrhages: Siderophor cells
• Psuedomelanosis: Hemosiderin + H₂S

Question 4

Hemosiderin: Histology

Answer 4

• Prussian blue (Perl’s reaction)
• Turnbulls technique

Question 5

Forms of hemoglobin

Answer 5

• Sulfhaemoglobin (H₂S): Greenish → Fades
• Methaemoglobin (Fe²⁺ & Fe³⁺): Dark brown
• Carboxi-haemoglobin (CO-intoxication)
  
  • Cherry pink discolouration, clearly visible in the brain